Title:
AGENT FOR IMPROVING MITOCHONDRIAL DYSFUNCTION, PREVENTATIVE OR THERAPEUTIC AGENT FOR DISEASES OR SYMPTOMS CAUSED BY MITOCHONDRIAL DYSFUNCTION, AND APPLICATIONS THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/093379
Kind Code:
A1
Abstract:
The present invention addresses the issue of providing a means for substantially improving mitochondrial dysfunction. One embodiment of this invention pertains to an agent for improving mitochondrial dysfunction, that includes, as an effective component thereof, a compound indicated by a formula, a stereoisomerism thereof, a salt of same, or a solvate of these. Another embodiment of this invention pertains to a pharmaceutical or a pharmaceutical composition for use in the prevention or treatment of diseases or symptoms caused by mitochondrial dysfunction, said pharmaceutical or a pharmaceutical composition including as an effective component thereof said compound, a stereoisomerism thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof.
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Inventors:
OSAKA HITOSHI (JP)
YAMAGATA TAKANORI (JP)
JIMBO ERIKO (JP)
MIYAUCHI AKIHIKO (JP)
ABE TAKAAKI (JP)
YAMAGATA TAKANORI (JP)
JIMBO ERIKO (JP)
MIYAUCHI AKIHIKO (JP)
ABE TAKAAKI (JP)
Application Number:
PCT/JP2018/041354
Publication Date:
May 16, 2019
Filing Date:
November 07, 2018
Export Citation:
Assignee:
UNIV JICHI MEDICAL (JP)
UNIV TOHOKU (JP)
UNIV TOHOKU (JP)
International Classes:
A61K31/407; A61K31/473; A61K31/5415; A61K31/5513; A61P3/10; A61P3/12; A61P9/10; A61P25/00; A61P27/02; A61P35/00; A61P43/00
Foreign References:
| JP2003506014A | 2003-02-18 | |||
| JP2006516652A | 2006-07-06 | |||
| JP2012041314A | 2012-03-01 | |||
| JP2014521678A | 2014-08-28 | |||
| JPS56166116A | 1981-12-21 | |||
| JP2016514697A | 2016-05-23 | |||
| JP2014505095A | 2014-02-27 | |||
| JP2005500337A | 2005-01-06 | |||
| JP2017214460A | 2017-12-07 |
Other References:
KHALIULIN, I. ET AL.: "Apomorphine prevents myocardial ischemia/reperfusion-induced oxidative stress in the rat heart", FREE RADICAL BIOLOGY & MEDICINE, vol. 37, no. 7, 2004, pages 969 - 976, XP004551425, DOI: doi:10.1016/j.freeradbiomed.2004.06.029
SHIMADA, S. ET AL.: "Activation of dopamine D4 receptors is protective against hypoxia/reoxygenation-induced cell death in HT22 cells", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 114, no. 2, 2010, pages 217 - 224, XP055608074, ISSN: 1347-8613, DOI: 10.1254/jphs.10134FP
GROSSINI, E. ET AL.: "Asenapine increases nitric oxide release and protects porcine coronary artery endothelial cells against peroxidation", VASCULAR PHARMACOLOGY, vol. 60, no. 3, March 2014 (2014-03-01), pages 127 - 141, XP055608077, ISSN: 1537-1891, DOI: 10.1016/j.vph.2014.01.008
WANG, H. ET AL.: "Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide25-35- induced oxidative stress and the ensuing apoptosis", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 81, no. 4, 9 June 2005 (2005-06-09), pages 572 - 580, XP055608080
STAVROVSKAYA, I. G. ET AL.: "Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 200, no. 2, 2004, pages 211 - 222, XP008045833, DOI: doi:10.1084/jem.20032053
BORGES, M. B. D. ET AL.: "Characterization of hydrophobic interaction and antioxidant properties of the phenothiazine nucleus in mitochondrial and model membranes", FREE RADICAL RESEARCH, vol. 44, no. 9, 6 September 2010 (2010-09-06), pages 1054 - 1063, XP055608085, ISSN: 1071-5762, DOI: 10.3109/10715762.2010.498826
JUNG, Y. S. ET AL.: "Apomorphine suppresses TNF-alpha- induced MMP-9 expression and cell invasion through inhibition of ERK/ AP -1 signaling pathway in MCF-7 cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 487, no. 4, 2 May 2017 (2017-05-02), pages 903 - 909, XP085017688, DOI: doi:10.1016/j.bbrc.2017.04.151
GUEVEN N.: "Idebenone for Leber's hereditary optic neuropathy.", DRUGS TODAY (BARC, vol. 52, no. 3, March 2016 (2016-03-01), pages 173 - 181
SHRADER WD ET AL., BIOORG MED CHEM LETT., vol. 21, no. 12, 24 April 2011 (2011-04-24), pages 3693 - 8
ARCE PM ET AL., ACS MED CHEM LETT., vol. 2, no. 8, 31 May 2011 (2011-05-31), pages 608 - 13
JOHNSON SC ET AL., SCIENCE, vol. 342, no. 6165, 20 December 2013 (2013-12-20), pages 1524 - 8
See also references of EP 3708161A4
SHIMADA, S. ET AL.: "Activation of dopamine D4 receptors is protective against hypoxia/reoxygenation-induced cell death in HT22 cells", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 114, no. 2, 2010, pages 217 - 224, XP055608074, ISSN: 1347-8613, DOI: 10.1254/jphs.10134FP
GROSSINI, E. ET AL.: "Asenapine increases nitric oxide release and protects porcine coronary artery endothelial cells against peroxidation", VASCULAR PHARMACOLOGY, vol. 60, no. 3, March 2014 (2014-03-01), pages 127 - 141, XP055608077, ISSN: 1537-1891, DOI: 10.1016/j.vph.2014.01.008
WANG, H. ET AL.: "Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide25-35- induced oxidative stress and the ensuing apoptosis", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 81, no. 4, 9 June 2005 (2005-06-09), pages 572 - 580, XP055608080
STAVROVSKAYA, I. G. ET AL.: "Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 200, no. 2, 2004, pages 211 - 222, XP008045833, DOI: doi:10.1084/jem.20032053
BORGES, M. B. D. ET AL.: "Characterization of hydrophobic interaction and antioxidant properties of the phenothiazine nucleus in mitochondrial and model membranes", FREE RADICAL RESEARCH, vol. 44, no. 9, 6 September 2010 (2010-09-06), pages 1054 - 1063, XP055608085, ISSN: 1071-5762, DOI: 10.3109/10715762.2010.498826
JUNG, Y. S. ET AL.: "Apomorphine suppresses TNF-alpha- induced MMP-9 expression and cell invasion through inhibition of ERK/ AP -1 signaling pathway in MCF-7 cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 487, no. 4, 2 May 2017 (2017-05-02), pages 903 - 909, XP085017688, DOI: doi:10.1016/j.bbrc.2017.04.151
GUEVEN N.: "Idebenone for Leber's hereditary optic neuropathy.", DRUGS TODAY (BARC, vol. 52, no. 3, March 2016 (2016-03-01), pages 173 - 181
SHRADER WD ET AL., BIOORG MED CHEM LETT., vol. 21, no. 12, 24 April 2011 (2011-04-24), pages 3693 - 8
ARCE PM ET AL., ACS MED CHEM LETT., vol. 2, no. 8, 31 May 2011 (2011-05-31), pages 608 - 13
JOHNSON SC ET AL., SCIENCE, vol. 342, no. 6165, 20 December 2013 (2013-12-20), pages 1524 - 8
See also references of EP 3708161A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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