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Title:
AGENT FOR INCREASING INTESTINAL BUTYRIC ACID AND PROLIFERATION AGENT FOR BUTYRIC ACID-PRODUCING BACTERIA
Document Type and Number:
WIPO Patent Application WO/2017/159643
Kind Code:
A1
Abstract:
[Problem] To provide: an agent for increasing intestinal butyric acid which is capable of effectively increasing intestinal butyric acid; a food composition for increasing intestinal butyric acid; a proliferation agent for butyric acid-producing bacteria; a food composition for proliferating butyric acid-producing bacteria; a method for increasing intestinal butyric acid; a method for proliferating butyric acid-producing bacteria; a method for treating or preventing intestinal inflammation, fatty liver, diabetes, colon cancer or obesity using the same; and use of 1-kestose for producing a drug for treating or preventing the aforesaid diseases. [Solution] An agent for increasing intestinal butyric acid and a proliferation agent for butyric acid-producing bacteria, each comprising 1-kestose as an active ingredient. According to the present invention, intestinal butyric acid in humans or animals can be easily and effectively increased with little side effects or safety concerns. According to the present invention, furthermore, intestinal inflammation, fatty liver, diabetes, colon cancer or obesity can be prevented or treated by increasing intestinal butyric acid in humans or animals.

Inventors:
TOCHIO TAKUMI (JP)
KONISHI KENTA (JP)
NAKAMURA SAKI (JP)
Application Number:
PCT/JP2017/010066
Publication Date:
September 21, 2017
Filing Date:
March 14, 2017
Export Citation:
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Assignee:
B FOOD SCIENCE CO LTD (JP)
International Classes:
A61K31/702; A23L33/125; A61P1/04; A61P3/04; A61P3/10; A61P35/00; A61P43/00; C12N1/20
Foreign References:
JP2007512840A2007-05-24
JP2004049093A2004-02-19
JP2013147469A2013-08-01
JP2006321786A2006-11-30
JP2005306781A2005-11-04
Other References:
SUZUKI, NOBUYUKI ET AL.: "Superiority of 1- kestose, the Smallest Fructo-oligosaccharide, to a Synthetic Mixture of Fructo- oligosaccharides in the Selective Stimulating Activity on Bifidobacteria", BIOSCIENCE AND MICROFLORA, vol. 25, no. 3, 2006, pages 109 - 116, XP055421270, ISSN: 1349-8355
KIHARA, MINORU ET AL.: "Production of short- chain fatty acids and gas from various oligosaccharides by gut microbes of carp (Cyprinus carpio L.) in micro-scale batch culture", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, vol. 132, no. 2, 2002, pages 333 - 340, XP055121442, ISSN: 1095-6433
MURAI, KENJI ET AL.: "Effect of Oral Administration to Rats of Various Undigestible Saccharides on Fecal pH, Water Contents and Enzyme Activities", BIFIDOBACTERIA AND MICROFLORA, vol. 13, no. 2, 1994, pages 91 - 98, XP055421280
KILIAN, STEPHANUS ET AL.: "The effects of the novel bifidogenic trisaccharide, neokestose, on the human colonic microbiota", WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 18, no. 7, 2002, pages 637 - 644, XP055422858, ISSN: 1573-0972
BUYUKTORTOP, ASUMAN SAHIN ET AL.: "Determination and Comparison of Interaction Between Fructo- oligosaccharide Components and Lactobacillus acidophilus", SDU JOURNAL OF SCIENCE (E-JOURNAL, vol. 7, no. 1, 2012, pages 15 - 22, XP055577987, ISSN: 1306-7575
YASUNORI FUKUMORI ET AL.: "1-Kestose no Kinosei ni Tsuite (The effects of 1-Kestose on Physiological Funtions", PROCEEDINGS OF THE RESEARCH SOCIETY OF JAPAN SUGAR REFINERIES' TECHNOLOGISTS, vol. 52, 1 January 2004 (2004-01-01), pages 13 - 18, XP003021026, ISSN: 0370-9841
See also references of EP 3431089A4
Attorney, Agent or Firm:
SAGAWA Shingo et al. (JP)
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