Title:
AGENT FOR INDUCING ABNORMAL NUCLEIC ACID DEGRADATION
Document Type and Number:
WIPO Patent Application WO/2016/056645
Kind Code:
A1
Abstract:
In the present invention, an expression vector that promotes lysosome uptake of a target nucleic acid and identifies a protein that induces degradation of an abnormal nucleic acid, or includes the genes encoding the same, has been developed using RNautophagy/DNautophagy. The expression vector is provided as an active ingredient of an antiviral agent or a therapeutic agent for repeat expansion disorder, and the like. The expression vector including, in a state capable of expression, SIDT2 protein, an active mutant thereof, or polynucleotides encoding active fragments of the same, is provided as an agent for inducing abnormal nucleic acid degradation.
Inventors:
KABUTA TOMOHIRO (JP)
FUJIWARA YUUKI (JP)
WADA KEIJI (JP)
AIZAWA SHU (JP)
HASE KATSUNORI (JP)
FUJIWARA YUUKI (JP)
WADA KEIJI (JP)
AIZAWA SHU (JP)
HASE KATSUNORI (JP)
Application Number:
PCT/JP2015/078730
Publication Date:
April 14, 2016
Filing Date:
October 09, 2015
Export Citation:
Assignee:
NAT CT NEUROLOGY & PSYCHIATRY (JP)
International Classes:
A61K31/7088; A61K35/76; A61K48/00; A61P21/02; A61P25/00; A61P25/14; A61P31/12
Other References:
FUJIWARA,Y. ET AL.: "Discovery of a novel type of autophagy targetingRNA", AUTOPHAGY, vol. 9, no. 3, pages 403 - 409, ISSN: 1554-8627
FUJIWARA,Y. ET AL.: "Discovery uptake and degradation of DNA by lysosomes", AUTOPHAGY, vol. 9, no. 8, pages 1167 - 1171, ISSN: 1554-8627
HAYAT,M.A., AUTOPHAGY: CANCER, OTHER PATHOLOGIES, INFLAMMAT ION, IMMUNITY, INFECTION, AND AGING, vol. 1, 22 August 2013 (2013-08-22), pages 61 - 68, ISBN: 9780124055308
GAO,J. ET AL.: "SID1 transmembrane family, member 2 (Sidt2): A novel lysosomal membrane protein", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 402, no. 4, 26 November 2010 (2010-11-26), pages 588 - 594, XP027516826, ISSN: 0006-291X, DOI: doi:10.1016/j.bbrc.2010.09.133
MCEWAN,D.L. ET AL.: "Uptake of Extracellular Double-Stranded RNA by SID-2", MOL. CELL, vol. 47, no. 5, 14 September 2012 (2012-09-14), pages 746 - 754, XP028939336, ISSN: 1097-2765, DOI: doi:10.1016/j.molcel.2012.07.014
FUJIWARA,Y. ET AL.: "Discovery uptake and degradation of DNA by lysosomes", AUTOPHAGY, vol. 9, no. 8, pages 1167 - 1171, ISSN: 1554-8627
HAYAT,M.A., AUTOPHAGY: CANCER, OTHER PATHOLOGIES, INFLAMMAT ION, IMMUNITY, INFECTION, AND AGING, vol. 1, 22 August 2013 (2013-08-22), pages 61 - 68, ISBN: 9780124055308
GAO,J. ET AL.: "SID1 transmembrane family, member 2 (Sidt2): A novel lysosomal membrane protein", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 402, no. 4, 26 November 2010 (2010-11-26), pages 588 - 594, XP027516826, ISSN: 0006-291X, DOI: doi:10.1016/j.bbrc.2010.09.133
MCEWAN,D.L. ET AL.: "Uptake of Extracellular Double-Stranded RNA by SID-2", MOL. CELL, vol. 47, no. 5, 14 September 2012 (2012-09-14), pages 746 - 754, XP028939336, ISSN: 1097-2765, DOI: doi:10.1016/j.molcel.2012.07.014
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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