AGENT FOR INHIBITING MEMBRANE VIRUS REPRODUCTION, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING VIRAL INFECTIONS

Title:

AGENT FOR INHIBITING MEMBRANE VIRUS REPRODUCTION, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING VIRAL INFECTIONS

Document Type and Number:

WIPO Patent Application WO/2004/112804

Kind Code:

A1

Abstract:

The invention relates to the pharmaceutical industry, in particular to the development of an engine for inhibiting a membrane virus replication. The aim of said invention is to develop an agent based on fullerene-polycarbon anions for suppressing the activity of the membrane viruses during curing diseases provoked thereby. For this purpose, a group of inventions united by a common inventive conception is proposed. Said group consists of a method for producing compounds, a mechanism of action study, the production of pharmacological compositions and the development of therapeutic methods. The aim is achieved by selecting quantitative relations of components and reaction conditions ensuring the obtainment of polyaddition products. It is specified that the amino acid quantity is greater than the fullerene quantity by 50 times during a synthetic process. The thus obtained product exhibits an unlimited solubility in water, a required bioavailability, a high effectiveness of action on infected cells and a low toxicity. The basic substance content in a target product is equal to or greater than 90 %. Said process is adaptable to production and can be used for the pharmaceutical industry. Drug compositions and methods for treating virulent diseases provoked by a human immunodeficiency virus (HIV), herpes simplex virus (HSV) and hepatitis C virus (HCV) are also disclosed.

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Inventors:

RASNETSOV LEV DAVIDOVICH (RU)
SHVARTSAM IAKOV YUDELEVITCH (RU)
LYALINA IRINA KONSTANTINOVNA (RU)
RASNETSOVA BETTI EFIMOVNA (RU)

Application Number:

PCT/RU2004/000208

Publication Date:

December 29, 2004

Filing Date:

May 31, 2004

Export Citation:

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Assignee:

ZAKRYTOE AKTSIONERNOE OBSCHEST (RU)
RASNETSOV LEV DAVIDOVICH (RU)
SHVARTSAM IAKOV YUDELEVITCH (RU)
LYALINA IRINA KONSTANTINOVNA (RU)
RASNETSOVA BETTI EFIMOVNA (RU)

International Classes:

A61K31/197; A61K31/225; A61K31/785; A61K38/55; A61P31/18; A61K31/66; (IPC1-7): A61K33/00; A61K31/197; A61K31/785; A61K38/55; A61P31/18

Foreign References:

RU2196602C1	2003-01-20
RU2124022C1	1998-12-27
RU2107500C1	1998-03-27
US6204391B1	2001-03-20
US20030027870A1	2003-02-06
US5811460A	1998-09-22

Other References: