Title:
AGENT FOR INHIBITING VIRAL INFECTION AND/OR TREATING INFECTIOUS DISEASE, AND METHOD FOR INHIBITING VIRAL INFECTION AND/OR TREATING INFECTIOUS DISEASE
Document Type and Number:
WIPO Patent Application WO/2011/126071
Kind Code:
A1
Abstract:
Provided are an agent for inhibiting viral infection and/or treating an infectious disease whereby viral infection can be inhibited without being affected by a change in the virus such as the appearance of a subspecies or a variant, and a method for inhibiting viral infection and/or treating an infectious disease.
The entry of a virus into a cell is inhibited by using, as the active ingredient(s), a substance capable of inhibiting calcium ion influx into cells and/or a substance capable of forming a chelate with calcium ion. By using the aforesaid agent for inhibiting viral infection and treating an infectious disease, viral infection can be inhibited or a viral infectious disease can be treated, both over a wide range of virus strains for a prolonged period of time, without being affected by a change in the virus such as the appearance of a subspecies or a variant.
Inventors:
OHBA YUSUKE
MIYAZAKI TADAAKI
MIYAZAKI TADAAKI
Application Number:
PCT/JP2011/058804
Publication Date:
October 13, 2011
Filing Date:
April 07, 2011
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
OHBA YUSUKE
MIYAZAKI TADAAKI
OHBA YUSUKE
MIYAZAKI TADAAKI
International Classes:
A61K45/00; A61K31/198; A61K31/277; A61K31/4422; A61K31/554; A61P31/12; A61P31/16; C07D211/90; C07D281/10
Foreign References:
| JP2007533667A | 2007-11-22 | |||
| JP2008538354A | 2008-10-23 | |||
| US20060264510A1 | 2006-11-23 | |||
| JP2003512325A | 2003-04-02 |
Other References:
NUGENT, K.M. ET AL.: "Verapamil inhibits influenza A virus replication", ARCHIVES OF VIROLOGY, vol. 81, 1984, pages 163 - 170
CLOAD, P.A. ET AL.: "The inhibition of the RNA polymerase activity of influenza virus A by pyrophosphate analogues", NUCLEIC ACID RESEARCH, vol. 11, no. 16, 1983, pages 5621 - 5628
CLOAD, P.A. ET AL.: "The inhibition of the RNA polymerase activity of influenza virus A by pyrophosphate analogues", NUCLEIC ACID RESEARCH, vol. 11, no. 16, 1983, pages 5621 - 5628
Attorney, Agent or Firm:
SAGAWA Shingo et al. (JP)
Shingo Sagawa (JP)
Shingo Sagawa (JP)
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