Title:
AGENT FOR RECONSTRUCTING/ACTIVATING NEURAL NETWORK
Document Type and Number:
WIPO Patent Application WO/2017/030167
Kind Code:
A1
Abstract:
Provided is an agent that is effective, inter alia, for improving memory and cognitive function. The agent is composed of: at least one component (A) selected from naringenin, eriodictyol, 5,7-dihydroxychromone, caffeic acid, protocatechuic acid, glycosides thereof, and salts thereof; and a Siberian ginseng component (B).
Inventors:
TOHDA CHIHIRO (JP)
KOMATSU KATSUKO (JP)
KOMATSU KATSUKO (JP)
Application Number:
PCT/JP2016/074130
Publication Date:
February 23, 2017
Filing Date:
August 18, 2016
Export Citation:
Assignee:
RESILIO COMPANY LTD (JP)
International Classes:
A61K31/353; A61K31/192; A61K31/352; A61K31/58; A61K31/593; A61K31/7048; A61K36/185; A61K36/254; A61P9/10; A61P25/14; A61P25/16; A61P25/28; A61P43/00
Domestic Patent References:
| WO2014112145A1 | 2014-07-24 |
Foreign References:
| JP2007230878A | 2007-09-13 | |||
| JP2007161606A | 2007-06-28 | |||
| JP2008501343A | 2008-01-24 | |||
| JP2016027031A | 2016-02-18 |
Other References:
KHAN BADRUZZAMAN M. ET AL.: "Naringenin ameliorates Alzheimer's disease(AD)-type neurodegeneration with cognitive impairment(AD- TNDCI) caused by the intracerebroventricular- streptozotocin in rat model", NEUROCHEMISTRY INTERNATIONAL, vol. 61, 2012, pages 1081 - 1093, XP055366273
HEO JIN HO ET AL.: "Effect of Antioxidant Flavanone, Naringenin, from Citrus junos on Neuroprotection", J. AGRIC. FOOD CHEM., vol. 52, 2004, pages 1520 - 1525, XP055366274
WANG MEI DONG ET AL.: "Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease", INT. J. MOL. SCI., vol. 14, 2013, pages 5576 - 5586, XP055366278
LEEM EUNJU ET AL.: "Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease", JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 25, 2014, pages 801 - 806, XP028851753
KUMAR PUNEET ET AL.: "Protective effect of hesperidin and naringin against 3- nitropropionic acid induced Huntington's like symptoms in rats: Possible role of nitric oxide", BEHAVIOURAL BRAIN RESEARCH, vol. 206, 2010, pages 38 - 46, XP026709951
CUI JIAN QUN ET AL.: "Continual Naringin Treatment Benefits the Recovery of Traumatic Brain Injury in Rats Through Reducing Oxidative and Inflammatory Alterations", NEUROCHEM RES, vol. 39, 2014, pages 1254 - 1262, XP055366285
RONG WEI ET AL.: "Naringin Treatment Improves Functonal Recovery by Increasing BDNF and VEGF Expression, Inhibiting Neuronal Apoptosis After Spinal Cord Injury", NEUROCHEM RES, vol. 37, 2012, pages 1615 - 1623, XP035079120
CHIHIRO TODA ET AL.: "Shigoka Methanol Ekisu ni Yoru Synapse Saikeisei Sayo to Kioku Shogai Kaizen Sayo", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 126, 2006, pages 130
BAI YANJING ET AL.: "Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid beta (25-35)-induced neuritic atrophy in cultured rat cortical neurons", J NAT MED, vol. 65, 2011, pages 417 - 423, XP019917565
XINLUAN WANG ET AL.: "Osteogenic effects of flavonoid aglycones from an osteoprotective fraction of Drynaria fortunei-An in vitro efficacy study", PHYTOMEDICINE, vol. 18, 2011, pages 868 - 872, XP028096890
WONG CHUN KA ET AL.: "Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone", BRITISH JOURNAL OF NUTRITION, vol. 110, 2013, pages 475 - 485, XP055366287
YANG YOU ZHI ET AL.: "Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Abeta25-35-Induced Axonal Atrophy", NATURAL PRODUCT, vol. 78, 24 August 2015 (2015-08-24), pages 2297 - 2300, XP055366291
HEO JIN HO ET AL.: "Effect of Antioxidant Flavanone, Naringenin, from Citrus junos on Neuroprotection", J. AGRIC. FOOD CHEM., vol. 52, 2004, pages 1520 - 1525, XP055366274
WANG MEI DONG ET AL.: "Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease", INT. J. MOL. SCI., vol. 14, 2013, pages 5576 - 5586, XP055366278
LEEM EUNJU ET AL.: "Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease", JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 25, 2014, pages 801 - 806, XP028851753
KUMAR PUNEET ET AL.: "Protective effect of hesperidin and naringin against 3- nitropropionic acid induced Huntington's like symptoms in rats: Possible role of nitric oxide", BEHAVIOURAL BRAIN RESEARCH, vol. 206, 2010, pages 38 - 46, XP026709951
CUI JIAN QUN ET AL.: "Continual Naringin Treatment Benefits the Recovery of Traumatic Brain Injury in Rats Through Reducing Oxidative and Inflammatory Alterations", NEUROCHEM RES, vol. 39, 2014, pages 1254 - 1262, XP055366285
RONG WEI ET AL.: "Naringin Treatment Improves Functonal Recovery by Increasing BDNF and VEGF Expression, Inhibiting Neuronal Apoptosis After Spinal Cord Injury", NEUROCHEM RES, vol. 37, 2012, pages 1615 - 1623, XP035079120
CHIHIRO TODA ET AL.: "Shigoka Methanol Ekisu ni Yoru Synapse Saikeisei Sayo to Kioku Shogai Kaizen Sayo", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 126, 2006, pages 130
BAI YANJING ET AL.: "Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid beta (25-35)-induced neuritic atrophy in cultured rat cortical neurons", J NAT MED, vol. 65, 2011, pages 417 - 423, XP019917565
XINLUAN WANG ET AL.: "Osteogenic effects of flavonoid aglycones from an osteoprotective fraction of Drynaria fortunei-An in vitro efficacy study", PHYTOMEDICINE, vol. 18, 2011, pages 868 - 872, XP028096890
WONG CHUN KA ET AL.: "Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone", BRITISH JOURNAL OF NUTRITION, vol. 110, 2013, pages 475 - 485, XP055366287
YANG YOU ZHI ET AL.: "Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Abeta25-35-Induced Axonal Atrophy", NATURAL PRODUCT, vol. 78, 24 August 2015 (2015-08-24), pages 2297 - 2300, XP055366291
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
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