Title:
AGENT FOR PREVENTING OR AMELIORATING PRURITUS
Document Type and Number:
WIPO Patent Application WO/2022/250085
Kind Code:
A1
Abstract:
A new target molecule for pruritis has been discovered, and a novel means for eliminating pruritis is provided. This agent for preventing or ameliorating intractable pruritis uses a C3a receptor antagonist as an active ingredient.
Inventors:
MATSUMOTO TOMOHIRO (JP)
YOKOTA MASAFUMI (JP)
ISHIKAWA JUNKO (JP)
TOMINAGA MITSUTOSHI (JP)
TAKAMORI KENJI (JP)
YOKOTA MASAFUMI (JP)
ISHIKAWA JUNKO (JP)
TOMINAGA MITSUTOSHI (JP)
TAKAMORI KENJI (JP)
Application Number:
PCT/JP2022/021408
Publication Date:
December 01, 2022
Filing Date:
May 25, 2022
Export Citation:
Assignee:
KAO CORP (JP)
International Classes:
A61K45/00; A61K8/44; A61K8/49; A61K8/64; A61K31/195; A61K31/198; A61K31/381; A61K38/08; A61P17/00; A61P17/04; A61P37/08; A61P43/00; A61Q19/00
Foreign References:
| JP2009532493A | 2009-09-10 | |||
| JP2010513530A | 2010-04-30 |
Other References:
YAGO, HISASHI: "Study of Plasma Levels of Chemical Mediators in the Hemodialysis Patients with Pruitus", OSAKA DAIGAKU IGAKU ZASSKI., OSAKA UNIVERSITY SOCIETY, OSAKA., JP, vol. 43, no. 9-12, 25 December 1991 (1991-12-25), JP , pages 757 - 771, XP009541531, ISSN: 0369-710X
REID ROBERT C., YAU MEI-KWAN, SINGH RANEE, HAMIDON JOHAN K., LIM JUNXIAN, STOERMER MARTIN J., FAIRLIE DAVID P.: "Potent Heterocyclic Ligands for Human Complement C3a Receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 57, no. 20, 23 October 2014 (2014-10-23), US , pages 8459 - 8470, XP093008542, ISSN: 0022-2623, DOI: 10.1021/jm500956p
ROWLEY JESSICA A., REID ROBERT C., POON EUNICE K. Y., WU KAI-CHEN, LIM JUNXIAN, LOHMAN RINK-JAN, HAMIDON JOHAN K., YAU MEI-KWAN, H: "Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 2, 23 January 2020 (2020-01-23), US , pages 529 - 541, XP093008544, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00927
CONOR C. G. SCULLY, JADE S. BLAKENEY, RANEE SINGH, HUY N. HOANG, GIOVANNI ABBENANTE, ROBERT C. REID, DAVID P. FAIRLIE: "Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 53, no. 13, 8 July 2010 (2010-07-08), pages 4938 - 4948, XP055066650, ISSN: 00222623, DOI: 10.1021/jm1003705
STRAYER ETHAN C., LU STEPHEN, RIBEIRO JOSE, ANDERSEN JOHN F.: "Salivary complement inhibitors from mosquitoes: Structure and mechanism of action", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 296, 1 January 2021 (2021-01-01), US , pages 100083, XP093008548, ISSN: 0021-9258, DOI: 10.1074/jbc.RA120.015230
HASHIMOTO Y ET AL., LIFE SCIENCES., vol. 76, no. 7, 31 December 2004 (2004-12-31), pages 783 - 94
IKOMA A ET AL., NATURE REVIEWS NEUROSCIENCE, vol. 7, no. 7, July 2006 (2006-07-01), pages 535 - 47
J AM ACAD DERMATOL., vol. 71, no. 1, July 2014 (2014-07-01), pages 116 - 132
FUTURE ONCOL., vol. 14, no. 24, October 2018 (2018-10-01), pages 2531 - 2541
LEWIS JE ET AL., FRONT ENDOCRINOL (LAUSANNE)., vol. 6, 2 February 2015 (2015-02-02), pages 3
CERO C ET AL., STRUCTURE, vol. 22, no. 12, 2 December 2014 (2014-12-02), pages 1744 - 1753
PLOS ONE., vol. 12, no. 7, 10 July 2017 (2017-07-10), pages e0180822
J PHARMACOL SCI., vol. 112, no. 1, 2010, pages 56 - 63
REID RC. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 20, 23 October 2014 (2014-10-23), pages 8459 - 70
ROWLEY, J. A. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 2, 2020, pages 529 - 541
CONOR CG SCULLY. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 13, 2010, pages 4938 - 48
REID ROBERT C., YAU MEI-KWAN, SINGH RANEE, HAMIDON JOHAN K., LIM JUNXIAN, STOERMER MARTIN J., FAIRLIE DAVID P.: "Potent Heterocyclic Ligands for Human Complement C3a Receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 57, no. 20, 23 October 2014 (2014-10-23), US , pages 8459 - 8470, XP093008542, ISSN: 0022-2623, DOI: 10.1021/jm500956p
ROWLEY JESSICA A., REID ROBERT C., POON EUNICE K. Y., WU KAI-CHEN, LIM JUNXIAN, LOHMAN RINK-JAN, HAMIDON JOHAN K., YAU MEI-KWAN, H: "Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 2, 23 January 2020 (2020-01-23), US , pages 529 - 541, XP093008544, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00927
CONOR C. G. SCULLY, JADE S. BLAKENEY, RANEE SINGH, HUY N. HOANG, GIOVANNI ABBENANTE, ROBERT C. REID, DAVID P. FAIRLIE: "Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 53, no. 13, 8 July 2010 (2010-07-08), pages 4938 - 4948, XP055066650, ISSN: 00222623, DOI: 10.1021/jm1003705
STRAYER ETHAN C., LU STEPHEN, RIBEIRO JOSE, ANDERSEN JOHN F.: "Salivary complement inhibitors from mosquitoes: Structure and mechanism of action", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 296, 1 January 2021 (2021-01-01), US , pages 100083, XP093008548, ISSN: 0021-9258, DOI: 10.1074/jbc.RA120.015230
HASHIMOTO Y ET AL., LIFE SCIENCES., vol. 76, no. 7, 31 December 2004 (2004-12-31), pages 783 - 94
IKOMA A ET AL., NATURE REVIEWS NEUROSCIENCE, vol. 7, no. 7, July 2006 (2006-07-01), pages 535 - 47
J AM ACAD DERMATOL., vol. 71, no. 1, July 2014 (2014-07-01), pages 116 - 132
FUTURE ONCOL., vol. 14, no. 24, October 2018 (2018-10-01), pages 2531 - 2541
LEWIS JE ET AL., FRONT ENDOCRINOL (LAUSANNE)., vol. 6, 2 February 2015 (2015-02-02), pages 3
CERO C ET AL., STRUCTURE, vol. 22, no. 12, 2 December 2014 (2014-12-02), pages 1744 - 1753
PLOS ONE., vol. 12, no. 7, 10 July 2017 (2017-07-10), pages e0180822
J PHARMACOL SCI., vol. 112, no. 1, 2010, pages 56 - 63
REID RC. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 20, 23 October 2014 (2014-10-23), pages 8459 - 70
ROWLEY, J. A. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 2, 2020, pages 529 - 541
CONOR CG SCULLY. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 13, 2010, pages 4938 - 48
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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