Title:
AGENT FOR PREVENTING DETERIORATION IN VASCULAR ENDOTHELIAL FUNCTION OR IMPROVING VASCULAR ENDOTHELIAL FUNCTION
Document Type and Number:
WIPO Patent Application WO/2014/003154
Kind Code:
A1
Abstract:
An NO production-enhancing agent, which comprises citrulline or a salt thereof and serine or a salt thereof as active ingredients; an agent for preventing the deterioration in a vascular endothelial function or improving the vascular endothelial function, which comprises citrulline or a salt thereof and serine or a salt thereof as active ingredients; and a prophylactic or ameliorating agent for conditions associated with the deterioration in a vascular endothelial function, which comprises citrulline or a salt thereof and serine or a salt thereof as active ingredients.
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Inventors:
MORITA MASAHIKO (JP)
KOMATSU MIHO (JP)
HARA TAKAHIRO (JP)
KOMATSU MIHO (JP)
HARA TAKAHIRO (JP)
Application Number:
PCT/JP2013/067767
Publication Date:
January 03, 2014
Filing Date:
June 28, 2013
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
A61K31/198; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P15/10; A61P17/00; A61P21/00; A61P25/28; A61P43/00
Domestic Patent References:
| WO2007066642A1 | 2007-06-14 |
Foreign References:
| JPH09110686A | 1997-04-28 | |||
| JP2002226370A | 2002-08-14 | |||
| JP2002316929A | 2002-10-31 | |||
| JP2008273910A | 2008-11-13 | |||
| JP2006282648A | 2006-10-19 |
Other References:
MASAHIKO MORITA ET AL.: "L-Citrulline Keiko Sesshu ni yoru Hito deno Ko Domyaku Koka Sayo no Kento", THE JAPANESE JOURNAL OF SURGICAL METABOLISM AND NUTRITION, vol. 44, no. 3, 29 June 2010 (2010-06-29), pages 76
MASAHIKO MORITA ET AL.: "L-Citrulline no Kekkan Naihi Kino Shogai no Kaizen Koka", FOLIA PHARMACOL.JPN., vol. 136, 2010, pages 185
MASAHIKO MORITA ET AL.: "L-Citrulline Keiko Sesshu ni yoru Kashi Mukumi no Yokusei Koka", DAI 63 KAI THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 25 April 2011 (2011-04-25), pages 155
MASAHIKO MORITA ET AL.: "L-Citrulline Keiko Sesshu ga Hito no Hie Taikan Oyobi Massho Ketsuryu ni Oyobosu Koka", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 1 May 2010 (2010-05-01), pages 243
KAZUKI NARITA ET AL.: "L-Citrulline Sesshoku ni yoru Stress Yuhatsusei Hie Model ni Taisuru Kaizen Koka", ABSTRACTS OF 130TH ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN 2, 5 March 2010 (2010-03-05), pages 237
MITSUHIRO FURUSE ET AL.: "Regulation of stress response by amino acids", PROCEEDINGS OF JAPANESE SOCIETY FOR ANIMAL NUTRITION AND METABOLISM, vol. 52, no. 2, 15 October 2008 (2008-10-15), pages 31 - 41
MASAHIKO MORITA ET AL.: "L-Citrulline no Kekkan Naihi Kino Shogai no Kaizen Koka", FOLIA PHARMACOL.JPN., vol. 136, 2010, pages 185
MASAHIKO MORITA ET AL.: "L-Citrulline Keiko Sesshu ni yoru Kashi Mukumi no Yokusei Koka", DAI 63 KAI THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 25 April 2011 (2011-04-25), pages 155
MASAHIKO MORITA ET AL.: "L-Citrulline Keiko Sesshu ga Hito no Hie Taikan Oyobi Massho Ketsuryu ni Oyobosu Koka", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 1 May 2010 (2010-05-01), pages 243
KAZUKI NARITA ET AL.: "L-Citrulline Sesshoku ni yoru Stress Yuhatsusei Hie Model ni Taisuru Kaizen Koka", ABSTRACTS OF 130TH ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN 2, 5 March 2010 (2010-03-05), pages 237
MITSUHIRO FURUSE ET AL.: "Regulation of stress response by amino acids", PROCEEDINGS OF JAPANESE SOCIETY FOR ANIMAL NUTRITION AND METABOLISM, vol. 52, no. 2, 15 October 2008 (2008-10-15), pages 31 - 41
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