Title:
AGENT FOR PREVENTING AN INCREASE IN BLOOD PRESSURE AND AGENT FOR PREVENTING SACCHARIFICATION BOTH CONTAINING COFFEE BEAN EXTRACT AS ACTIVE INGREDIENT, AND METHODS FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2015/002209
Kind Code:
A1
Abstract:
The present invention relates to an agent for preventing an increase in blood pressure containing as the active ingredient a coffee bean extract, which is obtained through a subcritical treatment step under a temperature of 140-200˚C and a pressure of 0.15-1.8 MPa such that pressure is greater than saturated steam pressure at each temperature, wherein when the angiotensin-converting enzyme inhibiting activity is 50%, the coffee bean extract solid concentration (IC50 value) is 0.16 mg/mL or less. The present invention further relates to an agent for preventing saccharification, and also relates to methods for producing these agents. The present invention provides an agent for preventing an increase in blood pressure or an agent for preventing saccharification, either of which is derived from a coffee bean and has a higher activity, and methods for producing the same, as well as a method for producing a coffee bean extract having the effect of preventing an increase in blood pressure and the effect of preventing saccharification.
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Inventors:
HOBO AKIFUMI
TAKAYANAGI TOMOHIRO
TAKAYANAGI TOMOHIRO
Application Number:
PCT/JP2014/067589
Publication Date:
January 08, 2015
Filing Date:
July 01, 2014
Export Citation:
Assignee:
IBIDEN CO LTD (JP)
International Classes:
A61K36/18; A23F5/26; A61K8/97; A61K36/00; A61P9/12; A61P43/00; A61Q19/08
Domestic Patent References:
| WO2006080333A1 | 2006-08-03 |
Foreign References:
| JP2002087977A | 2002-03-27 | |||
| JP2009084214A | 2009-04-23 | |||
| JP2005204589A | 2005-08-04 | |||
| JP2011057561A | 2011-03-24 | |||
| JP2004033023A | 2004-02-05 |
Other References:
HISAYOSHI KATO ET AL.: "Coffee Mame no Arinkai Mizu Shori ni Okeru Kagakuteki Kenkyu", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2011, 2011, pages 225
INA H. ET AL.: "Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Angiotensin Converting Enzyme, Aldosterone and Corticosterone Levels in Rat Plasma.", NATURAL MEDICINES, vol. 57, no. 5, 2003, pages 178 - 180
ABEYWARDENA, M.Y. ET AL.: "Acute administration of chlorogenic acid reduces blood pressure in the rat.", HYPERTENSION, vol. 55, no. 6, 2010, pages 1493
HISAYOSHI KATO ET AL.: "Coffee Mame no Arinkai Chushutsu ni Kansuru Kenkyu", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, 2012
INA H. ET AL.: "Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Angiotensin Converting Enzyme, Aldosterone and Corticosterone Levels in Rat Plasma.", NATURAL MEDICINES, vol. 57, no. 5, 2003, pages 178 - 180
ABEYWARDENA, M.Y. ET AL.: "Acute administration of chlorogenic acid reduces blood pressure in the rat.", HYPERTENSION, vol. 55, no. 6, 2010, pages 1493
HISAYOSHI KATO ET AL.: "Coffee Mame no Arinkai Chushutsu ni Kansuru Kenkyu", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, 2012
Attorney, Agent or Firm:
HOSODA, YOSHINORI (JP)
Yoshinori Hosoda (JP)
Yoshinori Hosoda (JP)
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