Title:
AGENT FOR PREVENTING OR TREATING FRAILTY
Document Type and Number:
WIPO Patent Application WO/2021/215473
Kind Code:
A1
Abstract:
[Problem] To provide a medicament, etc., capable of preventing or treating frailty. [Solution] Frailty can be prevented or treated by orally administering silicon fine particles or placing the silicon fine particles on skin or mucosa. The silicon fine particles generate hydrogen when coming into contact with water having a pH of 7 or higher. Provided are an agent, a pharmaceutical composition, a medical device, and food or beverage which are for preventing or treating frailty, and which contain the silicon fine particles. For example, it is possible to prevent or treat attenuation of a physical ability, disability in activities of daily living, a decline in motor coordination, a decline in static sense, a decline in activity amount, and weight loss, in the frailty.
Inventors:
SHIMADA SHOICHI (JP)
KOYAMA YOSHIHISA (JP)
KONDO MAKOTO (JP)
USUI NORIYOSHI (JP)
KOBAYASHI HIKARU (JP)
KOBAYASHI YUKI (JP)
KOYAMA YOSHIHISA (JP)
KONDO MAKOTO (JP)
USUI NORIYOSHI (JP)
KOBAYASHI HIKARU (JP)
KOBAYASHI YUKI (JP)
Application Number:
PCT/JP2021/016176
Publication Date:
October 28, 2021
Filing Date:
April 21, 2021
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K33/00; A23L2/52; A23L33/16; A61P21/00; A61P25/00
Foreign References:
| JP2019214556A | 2019-12-19 |
Other References:
VINA, J ET AL.: "A free radical theory of frailt y", FREE RADICAL BIOLOGY AND MEDICINE, vol. 124, 2018, pages 358 - 363, XP085446115, DOI: 10.1016/j.freeradbiomed.2018.06.028
WELCH, A. A. ET AL.: "Cross-Sectional Associations Between Dietary Antioxidant Vitamins C, E and Carotenoid Intakes and Sarcopenic Indices in Women Aged 18-79 Years", CALCIFIED TISSUE INTERNATIONAL, vol. 106, December 2019 (2019-12-01), pages 331 - 342, XP037063311, DOI: 10.1007/s00223-019-00641-x
KIM, J ET AL.: "Au nanozyme-driven antioxidation for preventing frailty", COLLOIDS AND SURFACES B: BOINTERFACES, vol. 189, no. 110839, January 2020 (2020-01-01), pages 1 - 8, XP086128319, DOI: 10.1016/j.colsurfb.2020.110839
KOBAYASHI, S ET AL.: "INVERSE ASSOCIATION BETWEEN DIETARY HABITS WITH HIGH TOTAL ANTIOXIDANT CAPACITY AND PREVALENCE OF FRAILTY AMONG ELDERLY JAPANESE WOMEN: A MULTICENTER CROSS-SECTIONAL STUDY", J NUTR HEALTH AGING, vol. 18, no. 9, 2014, pages 827 - 836, XP035409704, DOI: 10.1007/s12603-014-0556-7
WELCH, A. A. ET AL.: "Cross-Sectional Associations Between Dietary Antioxidant Vitamins C, E and Carotenoid Intakes and Sarcopenic Indices in Women Aged 18-79 Years", CALCIFIED TISSUE INTERNATIONAL, vol. 106, December 2019 (2019-12-01), pages 331 - 342, XP037063311, DOI: 10.1007/s00223-019-00641-x
KIM, J ET AL.: "Au nanozyme-driven antioxidation for preventing frailty", COLLOIDS AND SURFACES B: BOINTERFACES, vol. 189, no. 110839, January 2020 (2020-01-01), pages 1 - 8, XP086128319, DOI: 10.1016/j.colsurfb.2020.110839
KOBAYASHI, S ET AL.: "INVERSE ASSOCIATION BETWEEN DIETARY HABITS WITH HIGH TOTAL ANTIOXIDANT CAPACITY AND PREVALENCE OF FRAILTY AMONG ELDERLY JAPANESE WOMEN: A MULTICENTER CROSS-SECTIONAL STUDY", J NUTR HEALTH AGING, vol. 18, no. 9, 2014, pages 827 - 836, XP035409704, DOI: 10.1007/s12603-014-0556-7
Attorney, Agent or Firm:
SHOJI Takashi et al. (JP)
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