Title:
AGENT FOR PREVENTING OR TREATING HTLV-I ASSOCIATED MYELOPATHY
Document Type and Number:
WIPO Patent Application WO/2013/054866
Kind Code:
A1
Abstract:
The present invention provides an agent for preventing or treating HAM and containing pentosan polysulfate or a pharmaceutically acceptable salt thereof as the active ingredient. The present invention also provides an agent for ameliorating HAM-associated motor disturbance and containing pentosan polysulfate or a pharmaceutically acceptable salt thereof as the active ingredient.
Inventors:
NAKAMURA TATSUFUMI (JP)
MATSUMOTO TADASHI (JP)
MATSUMOTO TADASHI (JP)
Application Number:
PCT/JP2012/076400
Publication Date:
April 18, 2013
Filing Date:
October 12, 2012
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
REQMED COMPANY LTD (JP)
REQMED COMPANY LTD (JP)
International Classes:
A61K31/737; A61P21/00; A61P25/00; A61P25/02; A61P31/14
Other References:
TATSUFUMI NAKAMURA ET AL.: "HAM/TSP ni Okeru HTLV-I no cell to cell spread ni Kan'yo suru small GTPases no Yakuwari to polysulfate ni yoru Shinki Chiryoho Kaihatsu e Muketa Kisoteki Kento", HTLV-I NO SEITAINAI KANSEN KAKUDAI KIJO NO KAIMEI TO SONO SEIGYO NI YORU HAM CHIRYOHO NO KAIHATSU NI KANSURU KENKYU HEISEI 20 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2009, pages 26 - 30, XP008174085
KAZUO TAJIMA: "ATL no Rinsho Byotaizo no Tokucho", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 0039-2359, vol. 165, 1993, pages 23 - 29, XP008174068
NAGASATO K ET AL.: "Heparin treatment in patients with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy: a preliminary study", J NEUROL SCI, vol. 115, 1993, pages 161 - 168, XP024345455
NAKAGAWA M. ET AL., J. NEUROVIROL., vol. 2, 1996, pages 345 - 55
MATSUO H. ET AL., LANCET, vol. 2, 1986, pages 1109 - 13
GRAHAM P. TAYLOR ET AL., RETROVIROLOGY, vol. 3, 2006, pages 63
NAGASATO K. ET AL., J. NEUROL. SCI., vol. 115, 1993, pages 161 - 8
IDA H. ET AL., ANTIVIRAL RESEARCH, vol. 23, 1994, pages 143 - 59
TATSUFUMI NAKAMURA ET AL.: "The role of small GTPases involved in cell-to-cell spread of HTLV-I in HAM/TSP and fundamental study aiming at development of novel treatment method with polysulfate, kokoro-no-kenkokagaku-kenkyujigyo", STUDY RELATING TO ELUCIDATION OF MECHANISM OF SPREAD OF HTLV-I INFECTION WITHIN THE BODY AND DEVELOPMENT OF HAM TREATMENT METHOD BY CONTROL THEREOF, YEAR 2008 SUMMARY AND SHARED RESEARCH REPORTS, 2009, pages 26 - 30
KUMAGAI K. ET AL., BMC CLINICAL PHARMACOLOGY, vol. 10, 2010, pages 7
BOHANNON RW; SMITH MB: "Interrater reliability of a Modified Ashworth Scale of Muscle Spasticity", PHYS THER, vol. 67, 1987, pages 206 - 207
OSAME M. ET AL.: "HTLV-I and the Nervous System", 1989, ALAN R. LISS, INC, article "HTLV-I-associated myelopathy (HAM", pages: 213 - 223
KAZUO TAJIMA: "ATL no Rinsho Byotaizo no Tokucho", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 0039-2359, vol. 165, 1993, pages 23 - 29, XP008174068
NAGASATO K ET AL.: "Heparin treatment in patients with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy: a preliminary study", J NEUROL SCI, vol. 115, 1993, pages 161 - 168, XP024345455
NAKAGAWA M. ET AL., J. NEUROVIROL., vol. 2, 1996, pages 345 - 55
MATSUO H. ET AL., LANCET, vol. 2, 1986, pages 1109 - 13
GRAHAM P. TAYLOR ET AL., RETROVIROLOGY, vol. 3, 2006, pages 63
NAGASATO K. ET AL., J. NEUROL. SCI., vol. 115, 1993, pages 161 - 8
IDA H. ET AL., ANTIVIRAL RESEARCH, vol. 23, 1994, pages 143 - 59
TATSUFUMI NAKAMURA ET AL.: "The role of small GTPases involved in cell-to-cell spread of HTLV-I in HAM/TSP and fundamental study aiming at development of novel treatment method with polysulfate, kokoro-no-kenkokagaku-kenkyujigyo", STUDY RELATING TO ELUCIDATION OF MECHANISM OF SPREAD OF HTLV-I INFECTION WITHIN THE BODY AND DEVELOPMENT OF HAM TREATMENT METHOD BY CONTROL THEREOF, YEAR 2008 SUMMARY AND SHARED RESEARCH REPORTS, 2009, pages 26 - 30
KUMAGAI K. ET AL., BMC CLINICAL PHARMACOLOGY, vol. 10, 2010, pages 7
BOHANNON RW; SMITH MB: "Interrater reliability of a Modified Ashworth Scale of Muscle Spasticity", PHYS THER, vol. 67, 1987, pages 206 - 207
OSAME M. ET AL.: "HTLV-I and the Nervous System", 1989, ALAN R. LISS, INC, article "HTLV-I-associated myelopathy (HAM", pages: 213 - 223
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
Download PDF:
Claims: