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Title:
AGENT FOR PREVENTING OR TREATING SMALL INTESTINAL DISORDER INDUCED BY NONSTEROIDAL ANTI-INFLAMMATORY DRUG AND PROTON PUMP INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/087842
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an agent for preventing or treating a small intestinal disorder induced by a nonsteroidal anti-inflammatory drug and a proton pump inhibitor. An agent for preventing or treating a small intestinal disorder induced by a nonsteroidal anti-inflammatory drug and a proton pump inhibitor, as well as fat related diseases and/or inflammation accompanying said small intestinal disorder, is provided which contains Bidifobacterium bifidum, Bidifobacterium longum, or Bidifobacterium infantis, or a treated product thereof.

Inventors:
OIKAWA Yosuke (Research and Development Division, 3-4, Ibukidai Higashimachi 7-chome, Nishi-ku, Kobe-sh, Hyogo 42, 〒6512242, JP)
TANAKA Yoshiki (Research and Development Division, 3-4, Ibukidai Higashimachi 7-chome, Nishi-ku, Kobe-sh, Hyogo 42, 〒6512242, JP)
OHNO Hiroshi (Research and Development Division, 3-4, Ibukidai Higashimachi 7-chome, Nishi-ku, Kobe-sh, Hyogo 42, 〒6512242, JP)
SHIMAKAWA Masaki (Research and Development Division, 3-4, Ibukidai Higashimachi 7-chome, Nishi-ku, Kobe-sh, Hyogo 42, 〒6512242, JP)
Application Number:
JP2018/039158
Publication Date:
May 09, 2019
Filing Date:
October 22, 2018
Export Citation:
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Assignee:
BIOFERMIN PHARMACEUTICAL CO., LTD. (1-1-2, Sannomiyacho Chuo-ku, Kobe-sh, Hyogo 21, 〒6500021, JP)
International Classes:
A61K35/745; A23L33/135; A61K8/99; A61K31/192; A61K31/4439; A61K31/616; A61P1/00; A61P29/00; A61P43/00; A61Q19/00
Domestic Patent References:
WO2007010977A12007-01-25
Foreign References:
JP2007507485A2007-03-29
Other References:
WALLACE JL. ET AL.: "Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis", GASTROENTEROLOGY, vol. 141, no. 4, 2011, pages 1314 - 1322, XP028305248
AMAGASE: "Effect of Probiotic Preparations on Loxoprofen-Induced Small Intestinal Lesions in Rats", ULCER RES., vol. 40, 2013, pages 25 - 29, ISSN: 0916-3301
LIM, YJ. ET AL.: "Abstract-Sa1787: In Vivo Effect of S-Pantoprazole, Polaprenzinc and Probiotics on Chronic Indomethacin Induced Small Intestinal Injuries", GASTROENTEROLOGY, vol. 148, no. 4, 2015, pages S-332, XP055613802
FUKUDA S ET AL.: "Bifidobacteria can protect from enteropathogenic infection through production of acetate", NATURE, vol. 469, no. 7331, 2011, pages 543 - 547, XP055008675, doi:10.1038/nature09646
VULEVIC J. ET AL.: "In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn-diacylglycerol by Bifidobacterium longun biovar infantis", JAPPL MICROBIOL., vol. 105, no. 5, 2008, pages 1678 - 1685, XP055613806, ISSN: 1364-5072
Attorney, Agent or Firm:
IWATANI, Ryo (KEIHAN Dojima Bldg. 6F, 1-31 Dojima 2-chome, Kita-ku, Osaka-sh, Osaka 03, 〒5300003, JP)
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