Title:
AGENT FOR PROMOTING SUBSTANCE INCORPORATION IN INTESTINAL TRACT
Document Type and Number:
WIPO Patent Application WO/2015/182470
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a means whereby a substance that is useful in intestinal tract immunity induction, such as a lactic acid bacterium, can be efficiently incorporated into the intestinal tract.
Provided are: an agent for promoting substance incorporation in the intestinal tract, said agent comprising a surface layer (S-layer) protein containing a peptide motif that is common to lactic acid bacteria belonging to the genus Lactobacillus; a complex that comprises the agent for promoting incorporation with a substance to be incorporated into the intestinal tract; a food, drink or medicine that comprises the complex; and a method for screening a lactic acid bacterium having a high ability to migrate into the intestinal tract, said screening method comprising measuring the expression amount of an S-layer protein in the cell surface layer of a lactic acid bacterium to be tested.
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Inventors:
HYAKUTAKE SAE (JP)
YAMAMOTO NAOYUKI (JP)
KANAYA TAKASHI (JP)
HIROTA TATSUHIKO (JP)
FUKUDA SHINJI (JP)
OHNO HIROSHI (JP)
YAMAMOTO NAOYUKI (JP)
KANAYA TAKASHI (JP)
HIROTA TATSUHIKO (JP)
FUKUDA SHINJI (JP)
OHNO HIROSHI (JP)
Application Number:
PCT/JP2015/064573
Publication Date:
December 03, 2015
Filing Date:
May 21, 2015
Export Citation:
Assignee:
CALPIS CO LTD (JP)
RIKEN (JP)
RIKEN (JP)
International Classes:
A61K47/42; A23K1/16; A23L1/30; A23L1/305; A61K38/00; A61K39/00; A61K39/39; A61P37/04
Domestic Patent References:
| WO2014167995A1 | 2014-10-16 | |||
| WO2006073145A1 | 2006-07-13 | |||
| WO1999051631A1 | 1999-10-14 |
Foreign References:
| JP2005528085A | 2005-09-22 |
Other References:
MOEINI, H. ET AL.: "Lactobacillus acidophilus as a live vehicle for oral immunization against chicken anemia virus", APPL MICROBIOL BIOTECHNOL, vol. 90, no. 1, 2011, pages 77 - 88, XP019889709, ISSN: 0175-7598
HYNONEN, U. ET AL.: "Lactobacillus surface layer proteins: structure, function and applications", APPL MICROBIOL BIOTECHNOL, vol. 97, no. 12, 2013, pages 5225 - 5243, XP035328899, ISSN: 0175-7598
XUEYAN, C. ET AL.: "Characterization of Surface Layer Proteins in Lactobacillus crispatus Isolate ZJ001", J. MICROBIOL. BIOTECHNOL., vol. 19, no. 10, 2009, pages 1176 - 1183, XP055242257
AATTOURI, N. ET AL.: "Oral ingestion of lactic- acid bacteria by rats increases lymphocyte proliferation and interferon-y production", BRITISH JOURNAL OF NUTRITION, vol. 87, no. 04, 2002, pages 367 - 373, XP055242259, ISSN: 0007-1145
HOLLMANN, A. ET AL.: "S-layer proteins from lactobacilli as vaccine delivery systems", INTERNATIONAL JOURNAL OF MICROBIOLOGY RESEARCH, vol. 2, no. 2, 2010, pages 30 - 43, XP055242260, ISSN: 0975-5276
HYNONEN, U. ET AL.: "Lactobacillus surface layer proteins: structure, function and applications", APPL MICROBIOL BIOTECHNOL, vol. 97, no. 12, 2013, pages 5225 - 5243, XP035328899, ISSN: 0175-7598
XUEYAN, C. ET AL.: "Characterization of Surface Layer Proteins in Lactobacillus crispatus Isolate ZJ001", J. MICROBIOL. BIOTECHNOL., vol. 19, no. 10, 2009, pages 1176 - 1183, XP055242257
AATTOURI, N. ET AL.: "Oral ingestion of lactic- acid bacteria by rats increases lymphocyte proliferation and interferon-y production", BRITISH JOURNAL OF NUTRITION, vol. 87, no. 04, 2002, pages 367 - 373, XP055242259, ISSN: 0007-1145
HOLLMANN, A. ET AL.: "S-layer proteins from lactobacilli as vaccine delivery systems", INTERNATIONAL JOURNAL OF MICROBIOLOGY RESEARCH, vol. 2, no. 2, 2010, pages 30 - 43, XP055242260, ISSN: 0975-5276
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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