Title:
AGENT FOR REDUCING RISK OF DISEASE ONSET RESULTING FROM NON-DIPPER TYPE INTRA-DAY BLOOD PRESSURE FLUCTUATION
Document Type and Number:
WIPO Patent Application WO/2012/063553
Kind Code:
A1
Abstract:
Provided is an agent that reduces the risk of disease onset resulting from non-dipper type intra-day blood pressure fluctuations and that can reduce the onset of disease resulting from intra-day blood pressure fluctuation risk and prone to occur towards the morning when early morning systolic blood pressure significantly decreases from that of the night time in humans having a particular non-dipper type intra-day blood pressure fluctuation pattern, particularly healthy individuals exhibiting normal SBP and DBP values. The agent is characterized by containing: a hydrolysate containing VPP and IPP and obtained by hydrolyzing animal milk protein; or a concentrate thereof.
Inventors:
TAKAHASHI MARI (JP)
YAMAMOTO NAOYUKI (JP)
YAMADA KAZUHISA (JP)
IKETANI TOSHIRO (JP)
YAMAMOTO NAOYUKI (JP)
YAMADA KAZUHISA (JP)
IKETANI TOSHIRO (JP)
Application Number:
PCT/JP2011/071025
Publication Date:
May 18, 2012
Filing Date:
September 14, 2011
Export Citation:
Assignee:
CALPIS CO LTD (JP)
TAKAHASHI MARI (JP)
YAMAMOTO NAOYUKI (JP)
YAMADA KAZUHISA (JP)
IKETANI TOSHIRO (JP)
TAKAHASHI MARI (JP)
YAMAMOTO NAOYUKI (JP)
YAMADA KAZUHISA (JP)
IKETANI TOSHIRO (JP)
International Classes:
A61K35/20; A61K35/74; A61K35/747; A61K38/00; A61K38/01; A61K38/02; A61K38/03; A61K38/06; A61K38/17; A61P9/08; A61P9/10; A61P9/12
Foreign References:
| JPH1198978A | 1999-04-13 |
Other References:
MIZUNO S ET AL.: "Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild hypertension", BR J NUTR., vol. 94, no. 1, 2005, pages 84 - 91
NAOYUKI YAMAMOTO: "Nyusankin no Ketsuatsu Koka Peptide", JAPANESE JOURNAL OF LACTIC ACID BACTERIA., vol. 18, no. 1, 2007, pages 22 - 30
HIROSHI IJIRI ET AL.: "Effect of Imidapril hydrochloride on blood pressure daily variations and autonomic nerve activities in essential hypertension. Evaluation by portable automatic blood pressure heart rate recorders", JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, vol. 29, no. 1/2, 1998, pages 301 - 302
AKIO FUJIMURA: "Series Jikan Yakubutsu Chiryo no Jissen (3) Junkanki Shikkan no Jikan Yakubutsu Chiryo", JOURNAL OF JAPANESE SOCIETY OF HOSPITAL PHARMACISTS, vol. 37, no. 1, 2001, pages 25 - 27
ISAO KONO ET AL.: "Chrono-therapy of imidapril for essential hypertension", YAMANASHI IGAKU, vol. 25, 1997, pages 103 - 108
NAOYUKI YAMAMOTO: "Nyusankin no Ketsuatsu Koka Peptide", JAPANESE JOURNAL OF LACTIC ACID BACTERIA., vol. 18, no. 1, 2007, pages 22 - 30
HIROSHI IJIRI ET AL.: "Effect of Imidapril hydrochloride on blood pressure daily variations and autonomic nerve activities in essential hypertension. Evaluation by portable automatic blood pressure heart rate recorders", JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, vol. 29, no. 1/2, 1998, pages 301 - 302
AKIO FUJIMURA: "Series Jikan Yakubutsu Chiryo no Jissen (3) Junkanki Shikkan no Jikan Yakubutsu Chiryo", JOURNAL OF JAPANESE SOCIETY OF HOSPITAL PHARMACISTS, vol. 37, no. 1, 2001, pages 25 - 27
ISAO KONO ET AL.: "Chrono-therapy of imidapril for essential hypertension", YAMANASHI IGAKU, vol. 25, 1997, pages 103 - 108
Attorney, Agent or Firm:
SAKAI Hajime et al. (JP)
Sakai 1 (JP)
Sakai 1 (JP)
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Claims: