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Patent Searching and Data


Title:
AGENT FOR REGENERATING VISUAL FUNCTION OR AGENT FOR PREVENTING DETERIORATION IN VISUAL FUNCTION
Document Type and Number:
WIPO Patent Application WO/2018/043707
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an agent for regenerating a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function regenerating ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-translocating receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-conjugated receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-translocating receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-conjugated receptor rhodopsin.

Inventors:
KURIHARA TOSHIHIDE (JP)
KATADA YUSAKU (JP)
KUNIMI HIROMITSU (JP)
TSUBOTA KAZUO (JP)
KANDORI HIDEKI (JP)
Application Number:
PCT/JP2017/031579
Publication Date:
March 08, 2018
Filing Date:
September 01, 2017
Export Citation:
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Assignee:
UNIV KEIO (JP)
NAGOYA INST TECH (JP)
International Classes:
A61K38/00; A61K31/7088; A61K35/76; A61K48/00; A61P27/02; C12N15/09; C07K14/195; C07K14/705; C07K19/00
Foreign References:
JP2016519063A2016-06-30
JP2009536219A2009-10-08
JPH1129599A1999-02-02
Other References:
SASAKI, K. ET AL.: "Chimeric Proton-Pumping Rhodopsins Containing the Cytoplasmic Loop of Bovine Rhodopsin", PLOS ONE, vol. 9, no. 3, 12 March 2014 (2014-03-12), pages e91323, XP055584279
GYOSEKI SHOKAI: "Introduction of Achievement : The Function of Chimeric Proteins of Animal and Microbial Rhodopsins", NEWSLETTER THE APRIL 2014 ISSUE, no. 8, April 2014 (2014-04-01), pages 32 - 37, XP055584289
BI ET AL.: "Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration", NEURON, vol. 50, no. 1, 2006, pages 23 - 33, XP002406402, DOI: doi:10.1016/j.neuron.2006.02.026
TOMITA ET AL.: "Restoration of the Majority of the Visual Spectrum by Using Modified Volvox Channelrhodopsin-1", MOLECULAR THERAPY, vol. 22, no. 8, 2014, pages 1434 - 1440
MARK, D. F. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 5662 - 5666
ZOLLER, M.J.; SMITH, M., NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487 - 6500
WANG, A. ET AL., SCIENCE, vol. 224, pages 1431 - 1433
DALBADIE-MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 6413
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
See also references of EP 3508212A4
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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