Title:
AGENT FOR SUPPRESSING AGGREGATION OF TDP-43, AGENT FOR SUPPRESSING CELL DEATH OF CELLS IN WHICH TDP-43 IS OVEREXPRESSED, AND AGENT FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH AGGREGATION OF TDP-43
Document Type and Number:
WIPO Patent Application WO/2023/171106
Kind Code:
A1
Abstract:
An agent for suppressing aggregation of TDP-43, the agent comprising at least one selected from the group consisting of cycloserine, terizidone, and salts thereof.
Inventors:
HORIMOTO KATSUHISA (JP)
KIBOKU TAKAYUKI (JP)
KIBOKU TAKAYUKI (JP)
Application Number:
PCT/JP2023/000180
Publication Date:
September 14, 2023
Filing Date:
January 06, 2023
Export Citation:
Assignee:
SOCIUM INC (JP)
International Classes:
A61K31/42; A61P21/00; A61P25/00; A61P43/00
Foreign References:
| JP2022500397A | 2022-01-04 | |||
| JP2018526345A | 2018-09-13 | |||
| US20110160260A1 | 2011-06-30 | |||
| JP2002511409A | 2002-04-16 |
Other References:
YOHEI IGUCHI: "Current status and prospects for elucidating the pathology of amyotrophic lateral sclerosis", PHARMA MEDICA, vol. 39, no. 9, 1 January 2021 (2021-01-01), pages 69 - 74, XP009548703
RYOTA HIKIAMI, SOZO MINAMIYAMA, MAKOTO URUSHITANI: "Amyotrophic lateral sclerosis - from the perspective of proteinopathy", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 273, no. 1, 1 January 2020 (2020-01-01), JP , pages 44 - 49, XP009548681, ISSN: 0039-2359
WATANABE SEIJI, INAMI HIDEKAZU, OIWA KOTARO, MURATA YURI, SAKAI SHOHEI, KOMINE OKIRU, SOBUE AKIRA, IGUCHI YOHEI, KATSUNO MASAHISA,: "Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43", CELL DEATH & DISEASE, vol. 11, no. 10, 23 October 2020 (2020-10-23), pages 909, XP093090539, DOI: 10.1038/s41419-020-03116-2
VACA GABRIELA, MARTINEZ‐GONZALEZ LORETO, FERNANDEZ ANA, ROJAS‐PRATS ELISA, PORRAS GRACIA, CUEVAS EVA P., GIL CARMEN, MARTINEZ ANA,: "Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 156, no. 3, 1 February 2021 (2021-02-01), GB , pages 379 - 390, XP093090542, ISSN: 0022-3042, DOI: 10.1111/jnc.15118
LAOS VERONICA, BISHOP DEZMOND, LANG CHRISTIAN A., MARSH NICOLE M., CANTRELL KRISTI LAZAR, BURATTO STEVEN K., SINGH AMBUJ K., BOWER: "Modulating ALS-Related Amyloidogenic TDP-43 307–319 Oligomeric Aggregates with Computationally Derived Therapeutic Molecules", BIOCHEMISTRY, vol. 59, no. 4, 4 February 2020 (2020-02-04), pages 499 - 508, XP093090545, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.9b00905
RYOTA HIKIAMI, SOZO MINAMIYAMA, MAKOTO URUSHITANI: "Amyotrophic lateral sclerosis - from the perspective of proteinopathy", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 273, no. 1, 1 January 2020 (2020-01-01), JP , pages 44 - 49, XP009548681, ISSN: 0039-2359
WATANABE SEIJI, INAMI HIDEKAZU, OIWA KOTARO, MURATA YURI, SAKAI SHOHEI, KOMINE OKIRU, SOBUE AKIRA, IGUCHI YOHEI, KATSUNO MASAHISA,: "Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43", CELL DEATH & DISEASE, vol. 11, no. 10, 23 October 2020 (2020-10-23), pages 909, XP093090539, DOI: 10.1038/s41419-020-03116-2
VACA GABRIELA, MARTINEZ‐GONZALEZ LORETO, FERNANDEZ ANA, ROJAS‐PRATS ELISA, PORRAS GRACIA, CUEVAS EVA P., GIL CARMEN, MARTINEZ ANA,: "Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 156, no. 3, 1 February 2021 (2021-02-01), GB , pages 379 - 390, XP093090542, ISSN: 0022-3042, DOI: 10.1111/jnc.15118
LAOS VERONICA, BISHOP DEZMOND, LANG CHRISTIAN A., MARSH NICOLE M., CANTRELL KRISTI LAZAR, BURATTO STEVEN K., SINGH AMBUJ K., BOWER: "Modulating ALS-Related Amyloidogenic TDP-43 307–319 Oligomeric Aggregates with Computationally Derived Therapeutic Molecules", BIOCHEMISTRY, vol. 59, no. 4, 4 February 2020 (2020-02-04), pages 499 - 508, XP093090545, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.9b00905
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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