AGENT FOR TREATING CONTRAST-INDUCED ACUTE KIDNEY INJURY

WIPO Patent Application WO/2021/206316

A1

The present invention provides a pharmaceutical composition for protecting the kidney by reducing contrast-induced nephrotoxicity or for treating contrast-induced acute kidney injury, comprising the compound of chemical formula 1, which is a pyrazole derivative, or a pharmaceutically acceptable salt thereof.

LEE SOO JIN (KR)
MOON SUNG HWAN (KR)

PCT/KR2021/003536

October 14, 2021

March 23, 2021

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APTABIO CO LTD (KR)

A61K31/4439; A61P13/12

KR101856444B1	2018-05-10
KR20140027833A	2014-03-07
KR20040094464A	2004-11-10
KR101840702B1	2018-03-22
KR20170086851A	2017-07-27
KR20200042899A	2020-04-24
KR20210036838A	2021-04-05
KR101280160B1	2013-06-28
KR101886894B1	2018-08-08
US20190388492A1	2019-12-26

JIN JOO CHA: "APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury", 1 April 2017 (2017-04-01), pages 1 - 7, XP055675260, [retrieved on 20200310], DOI: 10.1038/labinvest.2017.2
PERSSON PBHANSELL PLISS P: "Pathophysiology of contrast medium-induced nephropathy", KIDNEY INT, vol. 68, 2005, pages 14 - 22
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See also references of EP 4134079A4

KIM, Sung Ho (KR)

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