Title:
AGENT FOR TREATMENT OF MALIGNANT TUMORS
Document Type and Number:
WIPO Patent Application WO/2023/095929
Kind Code:
A1
Abstract:
Provided are: an agent for treatment of malignant tumors, the agent being characterized by containing an immune checkpoint inhibitor and by being used in combination with a boron neutron capture therapy; (i) an immune checkpoint inhibitor selected from the group consisting of an anti-PD-1 antibody, an anti-PD-L1 antibody, an anti-CTLA-4 antibody, an anti-LAG-3 antibody, an anti-TIM-3 antibody, an anti-TIGIT antibody, an anti-KIR antibody, a PD-L1/TGFβ trap inhibition fusion protein, and an anti-PD-1/CTLA-4 bispecific antibody; and (ii) a combination drug for treatment of malignant tumors, which is for patients who do not respond to the treatments with the immune checkpoint inhibitors containing a boron compound for use in a boron neutron capture therapy.
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Inventors:
MICHIUE HIROYUKI (JP)
Application Number:
PCT/JP2022/044053
Publication Date:
June 01, 2023
Filing Date:
November 29, 2022
Export Citation:
Assignee:
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
International Classes:
A61K31/69; A61K39/395; A61K41/00; A61K45/00; A61P35/00; A61P35/02; A61P43/00
Other References:
SATO MARIKO: "Evaluation of tumor cell immunity profile changes after BNCT", NCT LETTER, 1 August 2020 (2020-08-01), pages 1 - 45, XP093069400, Retrieved from the Internet [retrieved on 20230801]
SATO HIRO; OKONOGI NORIYUKI; NAKANO TAKASHI: "Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 25, no. 5, 3 April 2020 (2020-04-03), Singapore, pages 801 - 809, XP037106667, ISSN: 1341-9625, DOI: 10.1007/s10147-020-01666-1
ROGER ANISSA, FINET ADELINE, BORU BLANDINE, BEAUCHET ALAIN, MAZERON JEAN-JACQUES, OTZMEGUINE YVES, BLOM ASTRID, LONGVERT CHRISTINE: "Efficacy of combined hypo-fractionated radiotherapy and anti-PD-1 monotherapy in difficult-to-treat advanced melanoma patients", ONCOIMMUNOLOGY, vol. 7, no. 7, 3 July 2018 (2018-07-03), pages 1 - 8, XP093069405, DOI: 10.1080/2162402X.2018.1442166
BOMMAREDDY PRAVEEN K, ZLOZA ANDREW, RABKIN SAMUEL D., KAUFMAN HOWARD L.: "Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma", ONCOIMMUNOLOGY, vol. 8, no. 7, 3 July 2019 (2019-07-03), pages 1 - 14, XP093069411, DOI: 10.1080/2162402X.2019.1591875
FUKUDA HIROSHI: "Boron Neutron Capture Therapy (BNCT) for Cutaneous Malignant Melanoma Using 10B-p-Boronophenylalanine (BPA) with Special Reference to the Radiobiological Basis and Clinical Results", CELLS, vol. 10, no. 11, 1 January 2021 (2021-01-01), pages 1 - 13, XP093069416, DOI: 10.3390/cells10112881
TALA ACHKAR, AHMAD A. TARHINI: "The use of immunotherapy in the treatment of melanoma", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 10, no. 1, 24 December 2017 (2017-12-24), pages 1 - 9, XP055492889, DOI: 10.1186/s13045-017-0458-3
SHAN CHUAN-KUN; DU YI-BO; ZHAI XIAO-TIAN; WANG YUE-XUAN; LI YI; GONG JIAN-HUA; GE ZHI-JUAN; LIU XIU-JUN; ZHEN YONG-SU: "Pingyangmycin enhances the antitumor efficacy of anti-PD-1 therapy associated with tumor-infiltrating CD8+ T cell augmentation", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 87, no. 3, 1 March 2021 (2021-03-01), DE , pages 425 - 436, XP037372363, ISSN: 0344-5704, DOI: 10.1007/s00280-020-04209-7
SATO HIRO; OKONOGI NORIYUKI; NAKANO TAKASHI: "Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 25, no. 5, 3 April 2020 (2020-04-03), Singapore, pages 801 - 809, XP037106667, ISSN: 1341-9625, DOI: 10.1007/s10147-020-01666-1
ROGER ANISSA, FINET ADELINE, BORU BLANDINE, BEAUCHET ALAIN, MAZERON JEAN-JACQUES, OTZMEGUINE YVES, BLOM ASTRID, LONGVERT CHRISTINE: "Efficacy of combined hypo-fractionated radiotherapy and anti-PD-1 monotherapy in difficult-to-treat advanced melanoma patients", ONCOIMMUNOLOGY, vol. 7, no. 7, 3 July 2018 (2018-07-03), pages 1 - 8, XP093069405, DOI: 10.1080/2162402X.2018.1442166
BOMMAREDDY PRAVEEN K, ZLOZA ANDREW, RABKIN SAMUEL D., KAUFMAN HOWARD L.: "Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma", ONCOIMMUNOLOGY, vol. 8, no. 7, 3 July 2019 (2019-07-03), pages 1 - 14, XP093069411, DOI: 10.1080/2162402X.2019.1591875
FUKUDA HIROSHI: "Boron Neutron Capture Therapy (BNCT) for Cutaneous Malignant Melanoma Using 10B-p-Boronophenylalanine (BPA) with Special Reference to the Radiobiological Basis and Clinical Results", CELLS, vol. 10, no. 11, 1 January 2021 (2021-01-01), pages 1 - 13, XP093069416, DOI: 10.3390/cells10112881
TALA ACHKAR, AHMAD A. TARHINI: "The use of immunotherapy in the treatment of melanoma", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 10, no. 1, 24 December 2017 (2017-12-24), pages 1 - 9, XP055492889, DOI: 10.1186/s13045-017-0458-3
SHAN CHUAN-KUN; DU YI-BO; ZHAI XIAO-TIAN; WANG YUE-XUAN; LI YI; GONG JIAN-HUA; GE ZHI-JUAN; LIU XIU-JUN; ZHEN YONG-SU: "Pingyangmycin enhances the antitumor efficacy of anti-PD-1 therapy associated with tumor-infiltrating CD8+ T cell augmentation", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 87, no. 3, 1 March 2021 (2021-03-01), DE , pages 425 - 436, XP037372363, ISSN: 0344-5704, DOI: 10.1007/s00280-020-04209-7
Attorney, Agent or Firm:
ASAHINA & CO. (JP)
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