Title:
AGENT FOR TREATMENT OF NERVOUS SYSTEM DISEASE
Document Type and Number:
WIPO Patent Application WO/2019/124483
Kind Code:
A1
Abstract:
The purpose of this invention is to provide a drug which is useful in the treatment of nervous system disease. This drug, which contains vitamin B12 as an active ingredient, has an action of promoting the induction of M2 macrophages/microglia, an action of suppressing the induction of M1 macrophages/microglia, and an action of promoting nerve regeneration, and is extremely effective as a drug for the treatment of nervous system diseases, particularly central nervous system diseases such as cerebral infarction, dementia and spinal cord injury.
Inventors:
TANAKA HIROYUKI (JP)
YOSHIKAWA HIDEKI (JP)
MOCHIZUKI HIDEKI (JP)
MURASE TSUYOSHI (JP)
SASAKI TSUTOMU (JP)
BABA KOUSUKE (JP)
IWAHASHI TORU (JP)
NAIKI MITSURU (JP)
YOSHIKAWA HIDEKI (JP)
MOCHIZUKI HIDEKI (JP)
MURASE TSUYOSHI (JP)
SASAKI TSUTOMU (JP)
BABA KOUSUKE (JP)
IWAHASHI TORU (JP)
NAIKI MITSURU (JP)
Application Number:
PCT/JP2018/046945
Publication Date:
June 27, 2019
Filing Date:
December 20, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
International Classes:
A61K31/714; A61K9/08; A61P7/02; A61P9/00; A61P9/10; A61P25/00; A61P25/28; C07D487/22
Domestic Patent References:
| WO2011149036A1 | 2011-12-01 | |||
| WO2011043136A1 | 2011-04-14 |
Foreign References:
| JP2014511830A | 2014-05-19 | |||
| CN104688763A | 2015-06-10 | |||
| CN1261535A | 2000-08-02 | |||
| CN102631667A | 2012-08-15 | |||
| JP2016513694A | 2016-05-16 |
Other References:
SUZUKI, KOJI ET. AL.: "Electrospun nanofiber sheets incorporating methylcobalamin promote nerve regeneration and functional recovery in a rat sciatic nerve crush injury model", vol. 53, 5 February 2017 (2017-02-05), pages 250 - 259, XP055691124, DOI: 10.1016/j.actbio.2017.02.004
WATANABE, T. ET. AL.: "Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 122, no. 2, April 1994 (1994-04-01), pages 140 - 143, XP024165209
YAMAZAKI, KAZUTO ET. AL.: "Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse", NEUROSCIENCE LETTERS, vol. 170, no. 1, 28 March 1994 (1994-03-28), pages 195 - 197, XP024374271
ANONYMOUS: "Methycobal tablets", February 2014 (2014-02-01), JP, XP009522070, Retrieved from the Internet
ICHIMARU, S.: "Attempt to treat dementia patients with cerebrovascular disease by megadose of methyl B12", THE JAPANESE JOURNAL OF CLINICAL AND EXPERIMENTAL MEDECINE, vol. 66, no. 1, pages 310 - 316
CURRENT MEDICINAL CHEMISTRY, vol. 14, no. 3, 2007, pages 249 - 263
WATANABE, T. ET. AL.: "Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 122, no. 2, April 1994 (1994-04-01), pages 140 - 143, XP024165209
YAMAZAKI, KAZUTO ET. AL.: "Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse", NEUROSCIENCE LETTERS, vol. 170, no. 1, 28 March 1994 (1994-03-28), pages 195 - 197, XP024374271
ANONYMOUS: "Methycobal tablets", February 2014 (2014-02-01), JP, XP009522070, Retrieved from the Internet
ICHIMARU, S.: "Attempt to treat dementia patients with cerebrovascular disease by megadose of methyl B12", THE JAPANESE JOURNAL OF CLINICAL AND EXPERIMENTAL MEDECINE, vol. 66, no. 1, pages 310 - 316
CURRENT MEDICINAL CHEMISTRY, vol. 14, no. 3, 2007, pages 249 - 263
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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