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Title:
AGENT FOR TREATMENT OR PREVENTION OF MUSCULAR-DYSTROPHY-RELATED CARDIOMYOPATHY
Document Type and Number:
WIPO Patent Application WO/2019/176864
Kind Code:
A1
Abstract:
An agent for the treatment or prevention of muscular-dystrophy-related cardiomyopathy, the agent containing as an active ingredient a compound represented by formula (1) or a phamacologically acceptable salt or solvate thereof. [In formula (1), R1, R2, R3, R4, and R5 each independently are C1-6 alkyl groups that may contain halogen atoms.]

Inventors:
KATANOSAKA, Yuki (1-1 Tsushima-Naka 1-chome, Kita-ku, Okayama-sh, Okayama 30, 〒7008530, JP)
NARUSE, Keiji (1-1 Tsushima-Naka 1-chome, Kita-ku, Okayama-sh, Okayama 30, 〒7008530, JP)
UJIHARA, Yoshihiro (1-1 Tsushima-Naka 1-chome, Kita-ku, Okayama-sh, Okayama 30, 〒7008530, JP)
TODA, Tatsushi (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 01, 〒6578501, JP)
KANAGAWA, Motoi (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 01, 〒6578501, JP)
Application Number:
JP2019/009742
Publication Date:
September 19, 2019
Filing Date:
March 11, 2019
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (1-1 Tsushima-Naka 1-chome, Kita-ku Okayama-sh, Okayama 30, 〒7008530, JP)
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (1-1 Rokkodai-cho, Nada-ku Kobe-sh, Hyogo 01, 〒6578501, JP)
International Classes:
A61K31/165; A61P21/04
Domestic Patent References:
WO2017010382A12017-01-19
Foreign References:
US20140256644A12014-09-11
JP2015509922A2015-04-02
JP2017214337A2017-12-07
Other References:
ZHANG, CAIMEI ET AL.: "Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte T-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure", CIRCULATION, vol. 129, no. 17, 29 April 2014 (2014-04-29), pages 1742 - 1750, XP055636135
Attorney, Agent or Firm:
SETOUCHI INTERNATIONAL PATENT FIRM (Growth-2 Building, 4-9-1 Ima, Kita-ku, Okayama-sh, Okayama 75, 〒7000975, JP)
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