Title:
AGENTS THAT BIND TO AND INHIBIT HUMAN CYTOCHROME P450 2C8, 2C9, 2C18 AND 2C19
Document Type and Number:
WIPO Patent Application WO2000047627
Kind Code:
A9
Abstract:
The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C8, 2C9, 2C18, and 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of the various human cytochrome P450 2C family members and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C family members, and in methods of screening individuals for a poor metabolizing individual human P450 2C family phenotypes.
Inventors:
GELBOIN HARRY V (US)
GONZALEZ FRANK J (US)
KRAUSZ KRISTOPHER W (US)
GONZALEZ FRANK J (US)
KRAUSZ KRISTOPHER W (US)
Application Number:
PCT/US2000/003673
Publication Date:
November 15, 2001
Filing Date:
February 11, 2000
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
GELBOIN HARRY V (US)
GONZALEZ FRANK J (US)
KRAUSZ KRISTOPHER W (US)
GELBOIN HARRY V (US)
GONZALEZ FRANK J (US)
KRAUSZ KRISTOPHER W (US)
International Classes:
C07K16/40; C12N5/20; (IPC1-7): C07K16/40; G01N33/573; C12N5/20; C12Q1/26
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