AGENTS WHICH REGULATE, INHIBIT, OR MODULATE THE ACTIVITY AND/OR EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AS A UNIQUE MEANS TO BOTH LOWER INTRAOCULAR PRESSURE AND TREAT GLAUCOMATOUS RETINOPATHIES/OPTIC NEUROPATHIES

Title:

Document Type and Number:

WIPO Patent Application WO2003092584

Kind Code:

A3

Abstract:

The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of connective tissue growth factor (CTGF).

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Inventors:

FLEENOR DEBRA L (US)
SHEPARD ALLAN (US)
JACOBSON NASREEN (US)
PANG IOK-HOU (US)
CLARK ABBOT F (US)

Application Number:

PCT/US2003/012521

Publication Date:

July 01, 2004

Filing Date:

April 18, 2003

Export Citation:

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Assignee:

ALCON INC (CH)
FLEENOR DEBRA L (US)
SHEPARD ALLAN (US)
JACOBSON NASREEN (US)
PANG IOK-HOU (US)
CLARK ABBOT F (US)

International Classes:

A61F9/007; A61K31/00; A61K31/202; A61K31/404; A61K31/426; A61K31/427; A61K31/4439; A61K31/454; A61K31/519; A61K31/52; A61K45/00; A61P27/02; A61P27/06; C12N9/99; (IPC1-7): C12N9/99

Domestic Patent References:

WO2003027275A1

2003-04-03

Other References: