AGER-PEPTIDES AND USE THEREOF

WIPO Patent Application WO2006077101

A3

The invention relates to the identification, functionality and use of domains of the N-terminus of the receptor for Advanced Glycation End Products (AGER). Said domains are highly conserved in all AGER protein sequences, with the designated receptor multimerisation epitop (RME). They represent mediators for the AGER automatic association and heteromerisation with other proteins. The invention also relates to the identification, functionality and use of peptides which are derived from the C-domains of AGER (AGER-CDP). The inventive AGER-RMEs and AGER-CDPs are suitable as targets for identifying AGER-ligands, which modulate natural ligand exchange effects as immunogens for the active or passive immunisation of individuals, as diagnostic means which are used to identify immunogenic reactions, and as peptide ligands which are used to modulate protein-protein-exchange effects involving AGER.

HAHN ALFRED (DE)
LOEBBERT RALPH (DE)
TEUSCH NICOLE (DE)
MOELLER ACHIM (DE)

PCT/EP2006/000420

September 28, 2006

January 18, 2006

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ABBOTT GMBH & CO KG (DE)
HAHN ALFRED (DE)
LOEBBERT RALPH (DE)
TEUSCH NICOLE (DE)
MOELLER ACHIM (DE)

A61K39/00; C07K14/47; C07K14/705; C07K16/00

WO1997039121A1	1997-10-23
WO1997039125A1	1997-10-23
WO2004016229A2	2004-02-26
WO1999018987A1	1999-04-22
WO2001092892A2	2001-12-06
WO1999054485A1	1999-10-28

US20030087302A1

2003-05-08

PATENT ABSTRACTS OF JAPAN vol. 2003, no. 12 5 December 2003 (2003-12-05)
PATENT ABSTRACTS OF JAPAN vol. 2003, no. 12 5 December 2003 (2003-12-05)

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