AGGREGATE COMPOSITION FOR SUSTAINED−RELEASE PREPARATION, PROCESS FOR PRODUCING THE SAME, AND SUSTAINED−RELEASE PREPARATION CONTAINING THE SAME

WIPO Patent Application WO/2002/100425

A1

A composition for sustained−release protein or peptide medicines which contains a biologically active protein highly stably and from which a preparation can be easily produced&semi and a process for producing the composition. The aggregate composition for sustained−release preparations comprises a biologically active protein or peptide, an acidic mucopolysaccharide, and polyvalent metal ions and has been aggregated in a neutral region. The process comprises (1) preparing an acidic mucopolysaccharide solution, (2) adding to this solution a solution containing at least one member selected from the group consisting of biologically active proteins and peptides, (3) subsequently adding a solution of polyvalent metal ions at a neutral region, and (4) optionally adding serum protein to thereby yield an aggregate composition. The process may optionally further include adding a pharmaceutically acceptable additive to the aggregate composition and molding the mixture to obtain the target composition for sustained−release preparations.

IGARASHI RIE (JP)
KITAGAWA AKIRA (JP)
MIZUSHIMA YUTAKA (JP)

PCT/JP2002/004771

December 19, 2002

May 17, 2002

Click for automatic bibliography generation  

LTT INST CO LTD (JP)
IGARASHI RIE (JP)
KITAGAWA AKIRA (JP)
MIZUSHIMA YUTAKA (JP)

A61K9/00; A61K9/52; A61K47/36; A61K47/42; A61K47/48; (IPC1-7): A61K38/00; A61K9/52; A61K38/22; A61K47/02; A61K47/26; A61K47/34; A61K47/36; A61K47/42; A61K47/44

WO1999059549A1

1999-11-25

EP0913149A1

1999-05-06

Takahashi, Takeshi (Nihonbashi 3-chome Chuo-ku, Tokyo, JP)

View/Download PDF      PDF Help

Previous Patent: ANTIVIRAL COMPOSITION INCORPORATING LECTINS

Next Patent: VACCINE COMPLEX FOR PREVENTING OR TREATING LEISHMANIASES