Title:
AGING CONDITION EVALUATION METHOD, INFORMATION PRESENTATION METHOD, AND SCREENING METHOD FOR SUBSTANCE THAT AMELIORATES OR PREVENTS AGING CONDITION
Document Type and Number:
WIPO Patent Application WO/2019/098194
Kind Code:
A1
Abstract:
Provided are a novel aging condition evaluation method, a novel information presentation method, and a novel screening method for a substance that ameliorates or prevents an aging condition. A method to evaluate an aging condition of a subject according to the present invention has a step in which, after a correlation standard with regard to the aging condition has been created, a subject value is compared to the correlation standard, said subject value relating to the quantity of extracellular vesicles included in exosomes in blood serum, the quantity of advanced glycation end products of surface proteins of the extracellular vesicles, or a parameter that is based on these quantities.
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Inventors:
KAN KAEN (JP)
NISHIYAMA YUKIE (JP)
IKUO MARIKO (JP)
TAHARA HIDETOSHI (JP)
NISHIYAMA YUKIE (JP)
IKUO MARIKO (JP)
TAHARA HIDETOSHI (JP)
Application Number:
PCT/JP2018/041990
Publication Date:
May 23, 2019
Filing Date:
November 13, 2018
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
International Classes:
G01N33/53; G01N33/15; G01N33/50; G01N33/68
Foreign References:
| JP2018151276A | 2018-09-27 | |||
| JP2001161364A | 2001-06-19 | |||
| JPS5514401B2 | 1980-04-16 |
Other References:
OKADA MEGUMI ET AL.: "The functions and activity of exosomes in aging-related diseases", BIO CLINICA, vol. 29, no. 6, 10 June 2014 (2014-06-10), pages 22 (532) - 25 (535), XP009520600
LEHMANN, B. D. ET AL.: "Senescence-Associated Exosome Release from Human Prostate Cancer Cells", CANCER RESEARCH, vol. 68, no. 19, 1 October 2008 (2008-10-01), pages 7864 - 7871, XP055609418
KANGAS, R. ET AL.: "Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy", SCIENTIFIC REPORTS, vol. 7, no. 42702, 14 February 2017 (2017-02-14), pages 1 - 14, XP055609423
CAO, X-Y. ET AL.: "MicroRNA biomarkers of Parkinson' s disease in serum exosome-like microvesicles", NEUROSCIENCE LETTERS, vol. 644, 20 February 2017 (2017-02-20), pages 94 - 99, XP085142364, DOI: 10.1016/j.neulet.2017.02.045
See also references of EP 3712616A4
LEHMANN, B. D. ET AL.: "Senescence-Associated Exosome Release from Human Prostate Cancer Cells", CANCER RESEARCH, vol. 68, no. 19, 1 October 2008 (2008-10-01), pages 7864 - 7871, XP055609418
KANGAS, R. ET AL.: "Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy", SCIENTIFIC REPORTS, vol. 7, no. 42702, 14 February 2017 (2017-02-14), pages 1 - 14, XP055609423
CAO, X-Y. ET AL.: "MicroRNA biomarkers of Parkinson' s disease in serum exosome-like microvesicles", NEUROSCIENCE LETTERS, vol. 644, 20 February 2017 (2017-02-20), pages 94 - 99, XP085142364, DOI: 10.1016/j.neulet.2017.02.045
See also references of EP 3712616A4
Attorney, Agent or Firm:
HAYASHI Kazuyoshi et al. (JP)
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