Title:
AGING MARKER, METHOD FOR EVALUATING AGING INHIBITOR, AND CANCER INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/078037
Kind Code:
A1
Abstract:
Provided is a method for clarifying and using miRNA that participates in cell aging. An aging marker includes an miR-22 gene transcription product. A method for evaluating an aging inhibitor comprises: a step for measuring the amount of the miR-22 gene transcription product expressed in a sample in the presence and the absence of a compound to be tested; and a step for comparing the amount of the miR-22 gene transcription product expressed in the sample in the presence of the compound to be tested, with the amount of the miR-22 gene transcription product expressed in the sample in the absence of the compound to be tested. A cancer inhibitor contains the miR-22 gene transcription product as the active component, promotes cell aging and inhibits cancer infiltration and/or metastasis.
Inventors:
TAHARA HIDETOSHI (JP)
Application Number:
PCT/JP2010/072592
Publication Date:
June 30, 2011
Filing Date:
December 15, 2010
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
TAHARA HIDETOSHI (JP)
TAHARA HIDETOSHI (JP)
International Classes:
C12N15/09; A61K31/7088; A61K48/00; A61P35/00; A61P35/04; A61P43/00; C12Q1/68
Foreign References:
| JP2008519606A | 2008-06-12 | |||
| JP2006519008A | 2006-08-24 | |||
| JP2008500837A | 2008-01-17 | |||
| JP2008519606A | 2008-06-12 | |||
| JP2009288707A | 2009-12-10 | |||
| JP2010049928A | 2010-03-04 |
Other References:
HE CHUNLEI. ET AL.: "Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 388, 9 October 2009 (2009-10-09), pages 35 - 40
LAFFERTY-WHYTE KYLE. ET AL.: "Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1792, April 2009 (2009-04-01), pages 341 - 352
See also references of EP 2518144A4
BRUCE ALBERTS; ALEXANDER JOHNSON; JULIAN LEWIS; MARTIN RAFF; KEITH ROBERTS; PETER WALTER; KEIKO NAKAMURA; KENICHI MATSUBARA: "MOLECULAR BIOLOGY OF THE CELL", 20 December 2004, NEWTON PRESS, INC., pages: 1017 - 1018
LAFFERTY-WHYTE KYLE. ET AL.: "Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1792, April 2009 (2009-04-01), pages 341 - 352
See also references of EP 2518144A4
BRUCE ALBERTS; ALEXANDER JOHNSON; JULIAN LEWIS; MARTIN RAFF; KEITH ROBERTS; PETER WALTER; KEIKO NAKAMURA; KENICHI MATSUBARA: "MOLECULAR BIOLOGY OF THE CELL", 20 December 2004, NEWTON PRESS, INC., pages: 1017 - 1018
Attorney, Agent or Firm:
KIMURA MITSURU (JP)
Mitsuru Kimura (JP)
Mitsuru Kimura (JP)
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