Title:
AGITATION DEVICE FOR PRODUCING PLATELET, AND CONTROL METHOD FOR SAID AGITATION DEVICE
Document Type and Number:
WIPO Patent Application WO/2023/153401
Kind Code:
A1
Abstract:
[Problem] Conventionally, it has been known that the production efficiency of platelets can be optimized by agitating contents under the agitation condition that the shear force index is a predetermined value. By utilizing this, the present invention is to optimize the production efficiency of platelets further by using a maximum speed and an actual mean speed when blades move. [Solution] The present invention is characterized in that: an agitation device comprises an agitation container in which contents for producing platelets are contained, an agitation means for agitating the contents in the agitation container by rotation or reciprocating movement, and a control device which includes a storage unit and a calculation unit and which controls the rotation or reciprocating movement of the agitation means; and a method comprises a first step for obtaining a set maximum speed determination function indicating the relationship between the set maximum speed of the agitation means and a shear force index, a second step for obtaining the set maximum speed from a value of the desired shear force index by using the set maximum speed determination function, and a third step for agitating contents in the agitation container on the basis of the set maximum speed.
Inventors:
KATO YOSHIKAZU (JP)
ETO KOJI (JP)
NAKAMURA SOU (JP)
HAYASHI HIDEKI (JP)
FUJIO KOSUKE (JP)
HARADA YASUO (JP)
OKAMOTO HARUKI (JP)
ETO KOJI (JP)
NAKAMURA SOU (JP)
HAYASHI HIDEKI (JP)
FUJIO KOSUKE (JP)
HARADA YASUO (JP)
OKAMOTO HARUKI (JP)
Application Number:
PCT/JP2023/003996
Publication Date:
August 17, 2023
Filing Date:
February 07, 2023
Export Citation:
Assignee:
SATAKE MULTIMIX CORP (JP)
UNIV KYOTO (JP)
OTSUKA PHARMA CO LTD (JP)
MEGAKARYON CORP (JP)
UNIV KYOTO (JP)
OTSUKA PHARMA CO LTD (JP)
MEGAKARYON CORP (JP)
International Classes:
C12M1/02; B01F27/93; B01F33/25
Domestic Patent References:
| WO2019009364A1 | 2019-01-10 | |||
| WO2017077964A1 | 2017-05-11 |
Other References:
YUKITAKA ITO, SOU NAKAMURA, NAOSHI SUGIMOTO, TOMOHIRO SHIGEMORI, YOSHIKAZU KATO, MIKIKO OHNO, SHINYA SAKUMA, KEITARO ITO, HIROKI K: "Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production", CELL, ELSEVIER, AMSTERDAM NL, vol. 174, no. 3, 1 July 2018 (2018-07-01), Amsterdam NL , pages 636 - 648.e18, XP055567213, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.06.011
Attorney, Agent or Firm:
SAWAKI Norikazu et al. (JP)
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