Title:
AGOMELATINE SOFT CAPSULE PREPARATION
Document Type and Number:
WIPO Patent Application WO/2017/206096
Kind Code:
A1
Abstract:
Provided is an agomelatine soft capsule preparation, wherein the agomelatine soft capsule preparation is composed of a liquid composition and a soft capsule shell; the liquid composition is sealed inside the soft capsule shell; the liquid composition contains agomelatine, polyethylene glycol, a surfactant and a humectant; and the agomelatine is completely dissolved in the polyethylene glycol. The agomelatine soft capsule preparation not only has a good stability, but also improves the drug dissolution rate and solves the problem of poor bioavailability. In addition, due to the addition of a surfactant, only a comparatively small amount of PEG is needed for the dissolution of agomelatine per dose unit, such that the loading capacity of an agomelatine soft capsule in the present invention is comparatively small, thus improving the compliance of elderly patients or patients suffering from dysphagia.
Inventors:
PENG JUNQING (CN)
GU SONGEN (CN)
WANG ZHIYUN (CN)
GU SONGEN (CN)
WANG ZHIYUN (CN)
Application Number:
PCT/CN2016/084251
Publication Date:
December 07, 2017
Filing Date:
June 01, 2016
Export Citation:
Assignee:
ZHEJIANG HUAHAI PHARM CO LTD (CN)
International Classes:
A61K31/165; A61K9/48; A61K47/34; A61P25/24
Foreign References:
| CN103623423A | 2014-03-12 |
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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