Title:
AGONIST ANTI-TRK-C MONOCLONAL ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2001098361
Kind Code:
A9
Abstract:
The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
Inventors:
DEVAUX BRIGITTE (US)
HONGO JO-ANNE S (US)
PRESTA LEONARD G (US)
SHELTON DAVID L (US)
HONGO JO-ANNE S (US)
PRESTA LEONARD G (US)
SHELTON DAVID L (US)
Application Number:
PCT/US2001/020153
Publication Date:
March 06, 2003
Filing Date:
June 22, 2001
Export Citation:
Assignee:
GENENTECH INC (US)
DEVAUX BRIGITTE (US)
HONGO JO-ANNE S (US)
PRESTA LEONARD G (US)
SHELTON DAVID L (US)
DEVAUX BRIGITTE (US)
HONGO JO-ANNE S (US)
PRESTA LEONARD G (US)
SHELTON DAVID L (US)
International Classes:
A61K39/395; A61K48/00; A61P9/00; A61P25/00; A61P25/02; A61P25/28; C07K16/28; C07K16/32; C12N15/09; C12N5/10; C12N15/02; C12N15/13; C12P21/08; (IPC1-7): C12N15/13; C07K16/28; C12N5/10; C12N15/63; A61K39/395; A61P25/00; A61P25/28; A61P9/00
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