Title:
AGONIST TO G PROTEIN-COUPLED RECEPTOR G2A AND METHOD OF SCREENING G2A ACTIVITY CONTROLLER
Document Type and Number:
WIPO Patent Application WO/2006/137435
Kind Code:
A1
Abstract:
One or more oxidized fatty acids selected from among 9-hydroxyoctadecadienic acid, 9-hydroperoxyoctadecadienic acid, 13-hydroxyoctadecadienic acid, hydroxyeicosatetraenic acid and ricinolic acid are used as G2A agonists. By using these oxidized fatty acids as controls, a novel G2A agonist, an inverse agonist thereto or an antagonist thereto is screened.
Inventors:
IZUMI TAKASHI (JP)
OBINATA HIDERU (JP)
OBINATA HIDERU (JP)
Application Number:
PCT/JP2006/312405
Publication Date:
December 28, 2006
Filing Date:
June 21, 2006
Export Citation:
Assignee:
UNIV GUNMA NAT UNIV CORP (JP)
IZUMI TAKASHI (JP)
OBINATA HIDERU (JP)
IZUMI TAKASHI (JP)
OBINATA HIDERU (JP)
International Classes:
A61K31/201; A23L1/30; A61K31/202; A61P1/16; A61P3/04; A61P3/10; A61P9/10; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C12Q1/02; G01N33/15; G01N33/50; C12N15/09
Domestic Patent References:
| WO2003078466A1 | 2003-09-25 | |||
| WO2001019985A1 | 2001-03-22 |
Foreign References:
| JPH07291862A | 1995-11-07 | |||
| JP2000505435A | 2000-05-09 | |||
| JP2002535479A | 2002-10-22 | |||
| JP2001523456A | 2001-11-27 | |||
| JP2004049004A | 2004-02-19 |
Other References:
OBINATA H. ET AL.: "Identification of a 9-Hydroxyoctadecadienoic Acid and Other Oxidized Free Fatty Acids as Ligands of the G Protein-Coupled Receptor G2A", J. BIOL. CHEM., vol. 280, no. 49, 2005, pages 40676 - 40683, XP003005412
Attorney, Agent or Firm:
Kawaguchi, Yoshiyuki (4-10 Higashi Nihonbashi 3-chom, Chuo-ku Tokyo 04, JP)
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