Title:
AIEGENS FOR CANCER CELL IMAGING
Document Type and Number:
WIPO Patent Application WO/2018/014865
Kind Code:
A1
Abstract:
A luminogen exhibiting aggregation induced emission is provided, wherein Tl, T2 and T3 comprise one or more polyynes as a conjugated bridge. Another AIEgen comprising a hydrophilic pydium group as a strong electron- withdrawing group, a piperazine group as an electron-donating group, and a a-cyanostilbene, wherein the AIEgen exhibits aggregation induced emission. A method of synthesizing an AIEgen and a method of labeling are also provided.
Inventors:
TANG BENZHONG (CN)
SHI XIUJUAN (CN)
YU YEE YUNG (CN)
KWOK TSZ KIN (CN)
ZHAO ZHENG (CN)
ZHANG PENGFEI (CN)
SU HUIFANG (CN)
SHI XIUJUAN (CN)
YU YEE YUNG (CN)
KWOK TSZ KIN (CN)
ZHAO ZHENG (CN)
ZHANG PENGFEI (CN)
SU HUIFANG (CN)
Application Number:
PCT/CN2017/093831
Publication Date:
January 25, 2018
Filing Date:
July 21, 2017
Export Citation:
Assignee:
UNIV HONG KONG SCI & TECH (CN)
International Classes:
G01N21/64; C09K11/06; C12Q1/04; G01N33/53
Foreign References:
| CN103788940A | 2014-05-14 | |||
| CN103842472A | 2014-06-04 | |||
| CN104974745A | 2015-10-14 | |||
| US8129111B2 | 2012-03-06 | |||
| US9109155B2 | 2015-08-18 | |||
| US20140255696A1 | 2014-09-11 |
Other References:
HU , RONGRONG ET AL.: "AIE macromolecules: syntheses, structures and functionalities", CHEM.SOC.REV, vol. 43, 15 April 2014 (2014-04-15), pages 4494 - 4562, XP055454270
YU , CHRIS Y. Y. ET AL.: "A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission", JOURNAL OF MATERIALS CHEMISTRY B, 11 March 2016 (2016-03-11), pages 2614 - 2619, XP055454273
H ONG YUNING ET AL.: "Aggregation-induced emission", CHEM.SOC.REV, vol. 40, no. 11, 29 July 2011 (2011-07-29), pages 5361 - 5388, XP055454275
YU , CHRIS Y. Y. ET AL.: "A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission", JOURNAL OF MATERIALS CHEMISTRY B, 11 March 2016 (2016-03-11), pages 2614 - 2619, XP055454273
H ONG YUNING ET AL.: "Aggregation-induced emission", CHEM.SOC.REV, vol. 40, no. 11, 29 July 2011 (2011-07-29), pages 5361 - 5388, XP055454275
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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