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Title:
AKKERMANSIA MUCINIPHILA STRAIN HAVING EFFECT OF PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASES OR METABOLIC DISEASES, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/012834
Kind Code:
A1
Abstract:
The present invention relates to an Akkermansia muciniphila strain having an effect of preventing or treating degenerative brain or metabolic diseases and a use thereof. The intestinal microorganism, Akkermansia muciniphila strain, of the present invention exhibits an effect of improving an exercise control ability, a cognitive ability and a memory in an animal model with a degenerative brain disease such as Parkinson's disease or Alzheimer's disease. In addition, it was observed that in the case of oral administration (in vivo) of an Akkermansia muciniphila strain cultured in a mucin-free medium compared with an Akkermansia muciniphila strain cultured in a mucin-containing medium, the effect of ameliorating hyperlipemia, fatty liver, obesity and hyperglycemia occurring in the mouse model induced by a high fat diet was remarkable.

Inventors:
KIM, Byoung-Chan (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
LEE, Chul-Ho (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
NOH, Jung-Ran (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
KIM, Kyoung-Shim (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
KIM, Myung-Hee (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
KIM, Yong-Hoon (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
LEE, Sang Jun (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
CHANG, Dong-Ho (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
CHOI, Dong-Hee (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
HWANG, Jung Hwan (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
SEO, Yun-Jung (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
LEE, In-Bok (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
CHOI, Young-Keun (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
CHOI, Jung-Hyeon (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
Application Number:
KR2017/007370
Publication Date:
January 18, 2018
Filing Date:
July 11, 2017
Export Citation:
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Assignee:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
International Classes:
C12N1/20; A23K10/16; A23L33/135; A61K35/66; A61K35/74; C12R1/01
Attorney, Agent or Firm:
CHOI, Kyu Whan (Green International Patent and Law Office, 12th floor 745, Hanbat-daero,Seo-gu, Daejeon, 35209, KR)
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