Title:
ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES
Document Type and Number:
WIPO Patent Application WO/2014/057419
Kind Code:
A3
Abstract:
The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I employing an aldehyde acetal intermediate Formula (I), wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
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Inventors:
ACEMOGLU MURAT (CH)
HELLSTERN HERIBERT (DE)
RISS BERNARD (CH)
SPRECHER CHRISTIAN (CH)
HELLSTERN HERIBERT (DE)
RISS BERNARD (CH)
SPRECHER CHRISTIAN (CH)
Application Number:
PCT/IB2013/059197
Publication Date:
July 03, 2014
Filing Date:
October 08, 2013
Export Citation:
Assignee:
NOVARTIS AG (CH)
ACEMOGLU MURAT (CH)
HELLSTERN HERIBERT (DE)
RISS BERNARD (CH)
SPRECHER CHRISTIAN (CH)
ACEMOGLU MURAT (CH)
HELLSTERN HERIBERT (DE)
RISS BERNARD (CH)
SPRECHER CHRISTIAN (CH)
International Classes:
C07K11/02
Domestic Patent References:
| WO2009024527A1 | 2009-02-26 | |||
| WO2012143888A1 | 2012-10-26 |
Foreign References:
| EP0052200A1 | 1982-05-26 |
Other References:
YOKOKAWA F ET AL: "Synthetic studies of micropeptin T-20, a novel 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptide", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 42, no. 34, 20 August 2001 (2001-08-20), pages 5903 - 5908, XP004295953, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)01136-4
YOKOKAWA F ET AL: "Total synthesis of somamide A, an Ahp (3-amino-6-hydroxy-2-piperidone)-containing cyclic depsipeptide", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 43, no. 48, 25 November 2002 (2002-11-25), pages 8673 - 8677, XP004390459, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(02)02178-0
YOKOKAWA F ET AL: "Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 61, no. 6, 7 February 2005 (2005-02-07), pages 1459 - 1480, XP027860763, ISSN: 0040-4020, [retrieved on 20050207]
PETRA JOHANNESSON ET AL: "Angiotensin II Analogues Encompassing 5,9- and 5,10-Fused Thiazabicycloalkane Tripeptide Mimetics", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 22, 1 November 1999 (1999-11-01), pages 4524 - 4537, XP055098932, ISSN: 0022-2623, DOI: 10.1021/jm991089q
YOKOKAWA F ET AL: "Total synthesis of somamide A, an Ahp (3-amino-6-hydroxy-2-piperidone)-containing cyclic depsipeptide", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 43, no. 48, 25 November 2002 (2002-11-25), pages 8673 - 8677, XP004390459, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(02)02178-0
YOKOKAWA F ET AL: "Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 61, no. 6, 7 February 2005 (2005-02-07), pages 1459 - 1480, XP027860763, ISSN: 0040-4020, [retrieved on 20050207]
PETRA JOHANNESSON ET AL: "Angiotensin II Analogues Encompassing 5,9- and 5,10-Fused Thiazabicycloalkane Tripeptide Mimetics", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 22, 1 November 1999 (1999-11-01), pages 4524 - 4537, XP055098932, ISSN: 0022-2623, DOI: 10.1021/jm991089q
Attorney, Agent or Firm:
NOVARTIS AG (Basel, CH)
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