Title:
ALDIMINE-DERIVED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE
Document Type and Number:
WIPO Patent Application WO/2013/091062
Kind Code:
A3
Abstract:
The present invention comprises aldimine-derived compounds, pharmaceutical compositions containing such compounds and pharmaceutically acceptable excipients, beside the use thereof for treating fungal infections of medicinal and/or veterinary importance. Aldimines and derivatives thereof have been shown to exhibit antifungal activity equivalent to or better than that of commercially available medicinal drugs, such as fluconazole. Since these drugs are new, pathogen resistance to these drugs is quite low. Aldimine synthesis is carried out in a single-step process in which the reaction is completed in two minutes, with yields of 70-98%, making large-scale production possible, since it is a fast and low-cost process, when compared to the production process of other pharmaceuticals available.
Inventors:
DE FATIMA ANGELO (BR)
DE RESENDE STOIANOFF (BR)
DE ASSIS SANTOS DANIEL (BR)
APARECIDO SABINO ADAO (BR)
BRONDI ALVEZ ROSEMEIRE (BR)
MOREIRA DA SILVA CLEITON (BR)
VIVIANE BUZANELLO MARTINS CLEIDE (BR)
FURTADO FERREIRA MAGALHAES THAIS (BR)
LETICIA DA SILVA DANIELLE (BR)
KIILL GASPAROTO ALAN (BR)
DE RESENDE STOIANOFF (BR)
DE ASSIS SANTOS DANIEL (BR)
APARECIDO SABINO ADAO (BR)
BRONDI ALVEZ ROSEMEIRE (BR)
MOREIRA DA SILVA CLEITON (BR)
VIVIANE BUZANELLO MARTINS CLEIDE (BR)
FURTADO FERREIRA MAGALHAES THAIS (BR)
LETICIA DA SILVA DANIELLE (BR)
KIILL GASPAROTO ALAN (BR)
Application Number:
PCT/BR2012/000562
Publication Date:
October 10, 2013
Filing Date:
September 24, 2012
Export Citation:
Assignee:
UNIV MINAS GERAIS (BR)
FUNDACAO DE AMPARO A PESQUISA DE MINAS GERAIS FAPEMIG (BR)
DE FATIMA ANGELO (BR)
DE RESENDE STOIANOFF (BR)
DE ASSIS SANTOS DANIEL (BR)
APARECIDO SABINO ADAO (BR)
BRONDI ALVEZ ROSEMEIRE (BR)
MOREIRA DA SILVA CLEITON (BR)
VIVIANE BUZANELLO MARTINS CLEIDE (BR)
FURTADO FERREIRA MAGALHAES THAIS (BR)
LETICIA DA SILVA DANIELLE (BR)
KIILL GASPAROTO ALAN (BR)
FUNDACAO DE AMPARO A PESQUISA DE MINAS GERAIS FAPEMIG (BR)
DE FATIMA ANGELO (BR)
DE RESENDE STOIANOFF (BR)
DE ASSIS SANTOS DANIEL (BR)
APARECIDO SABINO ADAO (BR)
BRONDI ALVEZ ROSEMEIRE (BR)
MOREIRA DA SILVA CLEITON (BR)
VIVIANE BUZANELLO MARTINS CLEIDE (BR)
FURTADO FERREIRA MAGALHAES THAIS (BR)
LETICIA DA SILVA DANIELLE (BR)
KIILL GASPAROTO ALAN (BR)
International Classes:
C07C251/02; A61K31/13; A61P31/10; C07D307/02
Foreign References:
| US4198349A | 1980-04-15 | |||
| US20090298905A1 | 2009-12-03 |
Other References:
CLEITON M. DA SILVA ET AL.: "Schiff bases: A short review of their antimicrobial activities", JOURNAL OF ADVANCED RESEARCH, vol. 2, 2011, pages 1 - 8
MOHAMED N IBRAHIM ET AL.: "Synthesis, Characterization and Study of the Biological activity of Some Aldimines Derivatives", E-JOURNAL OF CHEMISTRY, vol. 3, no. 4, October 2006 (2006-10-01), pages 257 - 261
K. MOUNIKA ET AL.: "Synthesis, Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-Amino Benzoic acid and its Transition Metal Complexes", J. SCI. RES., vol. 2, no. 3, 2010, pages 513 - 524
S.ARULMURUGAN ET AL.: "Biological Activities of Schiff Base and Its Complexes: a Review", RASAYAN J. CHEM., vol. 3, no. 3, 2010, pages 385 - 410
MOHAMED N IBRAHIM ET AL.: "Synthesis, Characterization and Study of the Biological activity of Some Aldimines Derivatives", E-JOURNAL OF CHEMISTRY, vol. 3, no. 4, October 2006 (2006-10-01), pages 257 - 261
K. MOUNIKA ET AL.: "Synthesis, Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-Amino Benzoic acid and its Transition Metal Complexes", J. SCI. RES., vol. 2, no. 3, 2010, pages 513 - 524
S.ARULMURUGAN ET AL.: "Biological Activities of Schiff Base and Its Complexes: a Review", RASAYAN J. CHEM., vol. 3, no. 3, 2010, pages 385 - 410
Attorney, Agent or Firm:
DE CASTRO LEITE GORI, Ana Luiza (UnidadeAdministrative II, 2ยบ Andar, Sala 2008,CEP: -90, Belo Horizonte Minas Gerais, BR)
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