ALGIN OLIGOSACCHARIDES AND THE DERIVATIVES THEREOF AS WELL AS THE MANUFACTURE AND THE USE OF THE SAME

Title:

ALGIN OLIGOSACCHARIDES AND THE DERIVATIVES THEREOF AS WELL AS THE MANUFACTURE AND THE USE OF THE SAME

Document Type and Number:

WIPO Patent Application WO/2005/089776

Kind Code:

A1

Abstract:

The present invention provides algin oligosaccharides having polymerized degree of 2-22 and the derivatives thereof, such algin oligosaccharides are made of mannuronic acid bonded by ∝-1,4 glycosidic bond. The derivatives which the reduced terminal in position-1 is carboxyl radical can be obtained by oxidation. The invention also provides the manufacture of algin oligosaccharides and the derivatives thereof, which includes the alginate solution in water reacts in the reactor under the condition of high press, 100-120°C, pH2-6, for 2-6 hours, after the reaction completed, its pH value was adjusted to 7. The result oligosaccharides are oxidated in presence of the oxidant, and then produces the oxidated products. The algin oligosaccharides and the derivatives thereof of the invention can be used in the manufacture of medicaments for preventing Alzheimer’s dementia.

Inventors:

GENG MEIYU (CN)
XIN XIANLIANG (CN)
SUN GUANGQIANG (CN)

Application Number:

PCT/CN2005/000226

Publication Date:

September 29, 2005

Filing Date:

February 25, 2005

Export Citation:

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Assignee:

OCEAN UNIV CHINA (CN)
GENG MEIYU (CN)
XIN XIANLIANG (CN)
SUN GUANGQIANG (CN)

International Classes:

A61K31/702; A61P3/10; A61P25/28; C07H3/06; C08B37/00; (IPC1-7): A61K31/702; C08B37/00; C07H3/06; A61P25/28; A61P3/10

Foreign References:

CN1401786A	2003-03-12
CN1341665A	2002-03-27
CN1414002A	2003-04-30
CN1473836A	2004-02-11
CN1562050A	2005-01-12
CN1486988A	2004-04-07
CN1380342A	2002-11-20
CN1341664A	2002-03-27
CN1408360A	2003-04-09
CN1454992A	2003-11-12

Other References: