Title:
ALKENYL COMPOUNDS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2014/193647
Kind Code:
A3
Abstract:
The present invention provides novel substituted alkenyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
Inventors:
XI NING (US)
LI XIAOBO (CN)
LI XIAOBO (CN)
Application Number:
PCT/US2014/037856
Publication Date:
January 29, 2015
Filing Date:
May 13, 2014
Export Citation:
Assignee:
CALITOR SCIENCES LLC (US)
SUNSHINE LAKE PHARMA CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
A61K31/415
Foreign References:
| US20030004350A1 | 2003-01-02 |
Other References:
GUKY, ZT. ET AL.: "Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl- 5-(3,4,5-timethoxyphenyl)pyrazolo[4,3-e] [1,2,4]triazines.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 2, 2009, pages 891 - 900, XP025950222, Retrieved from the Internet doi:10.1016/j.ejmech.2008.05.026
Attorney, Agent or Firm:
CALITOR SCIENCES, LLC (Newbury Park, CA, US)
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