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Title:
ALKENYL SUBSTITUTED CYCLOALIPHATIC COMPOUNDS AS CHEMICAL INDUCERS OF PROXIMITY
Document Type and Number:
WIPO Patent Application WO/2011/163029
Kind Code:
A3
Abstract:
Methods of inducing proximity of chimeric molecules in a cell are provided. Aspects of the methods include contacting a cell with an amount of alkenyl substituted cycloaliphatic (ASC) inducer compound, e.g., abscisic acid, effective to induce proximity of first and second chimeric molecules. Also provided are compositions and kits for practicing various embodiments of the methods. Methods of the invention find use in a variety of different applications, including transcription induction applications.

Inventors:
LIANG FU-SEN (US)
CRABTREE GERALD R (US)
Application Number:
PCT/US2011/040503
Publication Date:
March 27, 2014
Filing Date:
June 15, 2011
Export Citation:
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Assignee:
UNIV LELAND STANFORD JUNIOR (US)
LIANG FU-SEN (US)
CRABTREE GERALD R (US)
International Classes:
A01N43/02; C07H5/06; A61K36/00; C12N15/87
Foreign References:
US20070184060A12007-08-09
US5871753A1999-02-16
US20100132071A12010-05-27
US20010044427A12001-11-22
US5866334A1999-02-02
Other References:
FUJII ET AL., IN VITRO RECONSTITUTION OF AN ABSCISIC ACID SIGNALLING PATHWAY., vol. 462, 3 December 2009 (2009-12-03), pages 661
PARK ET AL.: "Abscisic Acid Inhibits Type 2C Protein Phosphatases via the PYR/PYL Family of START Proteins.", SCIENCE, vol. 324, 2009, pages 1068
SANTIAGO ET AL.: "The abscisic acid receptor PYR1 in complex with abscisic acid.", NATURE, vol. 462, 3 December 2009 (2009-12-03)
FINKELSTEIN ET AL.: "The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor.", PLANT CELL, vol. 12, April 2000 (2000-04-01), pages 599 - 610
FINKELSTEIN ET AL.: "The Arabidopsis Abscisic Acid Response Locus ABI4 Encodes an APETALA 2 Domain Protein.", PLANT CELL, vol. 10, June 1998 (1998-06-01), pages 1043 - 1054
GIRAUDAT.: "Abscisic acid signaling.", CURRENT OPINION IN CELL BIOLOGY, vol. 7, 1995, pages 232 - 238
STILLWELL ET AL.: "AbscisicAcid EnhancesAggregation and Fusionof Phospholipid Vesicles.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 156, no. 1, 1988, pages 511 - 516
Attorney, Agent or Firm:
FIELD, Bret E. (Field & Francis Llp1900 University Avenue, Suite 20, East Palo Alto California, US)
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