Title:
ALKOXYL TERMINAL GROUP OLIGO-PEG MODIFIED AMINOPYRIMIDINE DERIVATIVE AND ANTITUMOR APPLICATION
Document Type and Number:
WIPO Patent Application WO/2018/209961
Kind Code:
A1
Abstract:
Disclosed is a pyrazolo[3,4-d]pyrimidine derivative as represented by formula (I). The compound provided by the present invention has significant growth inhibiting, apoptosis promoting and cell proliferation slowing effects on tumor cells, can be used for preventing and/or treating tumor-related diseases, and has a wide application prospect.
Inventors:
LI WEIMIN (CN)
HE YANG (CN)
CHAI YINGYING (CN)
ZHOU XINGLONG (CN)
CHEN BOJIANG (CN)
LI CHANGFU (CN)
HUANG RIDONG (CN)
CHEN HAI (CN)
HE YANG (CN)
CHAI YINGYING (CN)
ZHOU XINGLONG (CN)
CHEN BOJIANG (CN)
LI CHANGFU (CN)
HUANG RIDONG (CN)
CHEN HAI (CN)
Application Number:
PCT/CN2017/118481
Publication Date:
November 22, 2018
Filing Date:
December 26, 2017
Export Citation:
Assignee:
WEST CHINA HOSPTIAL SICHUAN UNIV (CN)
International Classes:
C07D487/04; A61K31/519; A61P35/00
Foreign References:
| CN107383015A | 2017-11-24 | |||
| CN107098909A | 2017-08-29 | |||
| CN106008527A | 2016-10-12 |
Other References:
ADITYA, K. ET AL.: "1,3-Disubstituted-4-Aminopyrazolo[3,4-d]Pyrimidines, a New Class of Potent Inhibitors for Phospholipase D", CHEM BIOL DRUG DES, vol. 84, 31 March 2014 (2014-03-31), XP055550613
SHADAB, M.S. ET AL.: "Pyrazo-lo[3,4-d]Pyrimidine Analogues: Synthesis, Characterization and Their in Vitro Antiamoebic Activity", MED CHEM RES, vol. 22, 6 May 2012 (2012-05-06), pages 776 - 777, XP055550617
BEETH, A. ET AL.: "Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases", NATURE CHEMICAL BIOLOGY, vol. 4, no. 11, 12 October 2008 (2008-10-12), XP007909493
SHADAB, M.S. ET AL.: "Pyrazo-lo[3,4-d]Pyrimidine Analogues: Synthesis, Characterization and Their in Vitro Antiamoebic Activity", MED CHEM RES, vol. 22, 6 May 2012 (2012-05-06), pages 776 - 777, XP055550617
BEETH, A. ET AL.: "Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases", NATURE CHEMICAL BIOLOGY, vol. 4, no. 11, 12 October 2008 (2008-10-12), XP007909493
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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