Title:
ALKYL AMINE DERIVATIVE AND LOCAL ANESTHETIC AGENT USING THE SAME
Document Type and Number:
WIPO Patent Application WO/1999/045914
Kind Code:
A1
Abstract:
A local anesthetic agent comprising, as an active constituent, an alkyl amine derivative having general formula (I) wherein A is a substituted or unsubstituted aryl or heteroaryl group; R?1¿ and R?2¿ may be the same or different and are a hydrogen atom, a lower alkyl group or the like; R?3¿ and R?4¿ may be the same or different, and are a hydrogen atom, a lower alkyl group or the like or form, together with a nitrogen atom to which they are bonded, a 5 to 7-membered, substituted or unsubstituted heterocyclic ring; with respect to R?5¿ and R?6¿, one is a hydrogen atom and the other is a lower alkoxyl group, or they together form an oxo group or a lower alkylenedioxy group optionally substituted with a lower alkyl group; and n is 1 or 2.
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Inventors:
OKADA SHIGEYA (JP)
ISHIHAMA YUTAKA (JP)
ICHIOKA TAKAHIRO (JP)
MATSUI TAKEAKI (JP)
YAMAZAKI HIROFUMI (JP)
HIJIKURO KOHSHI (JP)
NARUSE TOMOHIRO (JP)
HOSHINO TAKASHI (JP)
ISHIHAMA YUTAKA (JP)
ICHIOKA TAKAHIRO (JP)
MATSUI TAKEAKI (JP)
YAMAZAKI HIROFUMI (JP)
HIJIKURO KOHSHI (JP)
NARUSE TOMOHIRO (JP)
HOSHINO TAKASHI (JP)
Application Number:
PCT/JP1999/001136
Publication Date:
September 16, 1999
Filing Date:
March 08, 1999
Export Citation:
Assignee:
MARUHO KABUSHIKIKAISHA (JP)
OKADA SHIGEYA (JP)
ISHIHAMA YUTAKA (JP)
ICHIOKA TAKAHIRO (JP)
MATSUI TAKEAKI (JP)
YAMAZAKI HIROFUMI (JP)
HIJIKURO KOHSHI (JP)
NARUSE TOMOHIRO (JP)
HOSHINO TAKASHI (JP)
OKADA SHIGEYA (JP)
ISHIHAMA YUTAKA (JP)
ICHIOKA TAKAHIRO (JP)
MATSUI TAKEAKI (JP)
YAMAZAKI HIROFUMI (JP)
HIJIKURO KOHSHI (JP)
NARUSE TOMOHIRO (JP)
HOSHINO TAKASHI (JP)
International Classes:
C07D233/60; C07D249/08; C07D277/24; C07D307/52; (IPC1-7): A61K31/135; A61K31/34; A61K31/40; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/47; A61K31/495; C07C217/08; C07C251/08; C07D215/14; C07D233/60; C07D241/42; C07D249/08; C07D257/04; C07D261/08; C07D263/32; C07D277/24; C07D277/64; C07D307/52; C07D307/81; C07D333/22; C07D333/32; C07D333/56; C07D401/06; C07D403/06; C07D405/06; C07D405/14; C07D407/04; C07D409/04; C07D409/06; C07D409/14; C07D413/04; C07D413/06; C07D417/06; C07D417/14
Domestic Patent References:
| WO1995018092A1 | 1995-07-06 |
Foreign References:
| JPS50142575A | 1975-11-17 | |||
| JPS497283A | 1974-01-22 | |||
| EP0423524A2 | 1991-04-24 | |||
| EP0404233A2 | 1990-12-27 | |||
| EP0404232A1 | 1990-12-27 | |||
| EP0004000A1 | 1979-09-19 |
Other References:
OTSU T., NAGAO T., ONO H.: "MUSCLE RELAXANT ACTION OF MS-322, A NEW CENTRALLY ACTING MUSCLE RELAXANT, IN RATS.", GENERAL PHARMACOLOGY., PERGAMON PRESS, OXFORD., GB, vol. 30., no. 03., 1 January 1998 (1998-01-01), GB, pages 393 - 398., XP002920572, ISSN: 0306-3623, DOI: 10.1016/S0306-3623(97)00275-9
MGONZO R, GERONIKAKI A, THEOPHILIDIS G: "SYNTHESIS OF NEW THIAZOLE DERIVATIVES AND COMPARATIVE STUDY OF THEIR LOCAL ANESTHETIC ACTIVITY USING THE EVOKED ACTION POTENTIAL IN THE SCIATIC NERVE", RESEARCH COMMUNICATIONS IN PHARMACOLOGY AND TOXICOLOGY, PJD PUBLICATIONS, WESTBURY, NY, US, vol. 01, no. 02/03, 1 January 1996 (1996-01-01), US, pages 136 - 148, XP002920573, ISSN: 1087-1101
MGONZO R, GERONIKAKI A, THEOPHILIDIS G: "SYNTHESIS OF NEW THIAZOLE DERIVATIVES AND COMPARATIVE STUDY OF THEIR LOCAL ANESTHETIC ACTIVITY USING THE EVOKED ACTION POTENTIAL IN THE SCIATIC NERVE", RESEARCH COMMUNICATIONS IN PHARMACOLOGY AND TOXICOLOGY, PJD PUBLICATIONS, WESTBURY, NY, US, vol. 01, no. 02/03, 1 January 1996 (1996-01-01), US, pages 136 - 148, XP002920573, ISSN: 1087-1101
Attorney, Agent or Firm:
Nogawa, Shintaro (Nishitenma 5-chome Kita-ku Osaka-shi Osaka, JP)
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