Title:
ALKYLENEDIAMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1995/026959
Kind Code:
A1
Abstract:
A novel alkylenediamine derivative having the effect of inhibiting dysuria occuring under a high intravesical pressure and represented by general formula (1) wherein R1 represents hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, nitro, amino, cyano, etc.; R2 represents hydrogen, alkyl, aryl, etc.; R3 and R4 represent each alkyl, etc., or R3 and R4 are combined together to form an optionally substituted heterocyclic group; k represents an integer of 1 to 4; m an n represent each an integer of 0 to 4; p+q = 0 to 4, wherein p is 0, 1 or 2 and q is 0 or 1; and w, x, y and z represent each an integer of 0 to 2, and w+x+y+z = 1 or 2, provided when R1 to R4 represent each a specifically limited group, w+x+y+z may be 0.
More Like This:
Inventors:
MASAKI MITSUO (JP)
MIYAKE NORIHISA (JP)
TENDO ATSUSHI (JP)
ISHIDA MICHIKO (JP)
SHINOZAKI ATSUHIKO (JP)
NOMURA YUTAKA (JP)
GOTO YASUNORI (JP)
MIYAKE NORIHISA (JP)
TENDO ATSUSHI (JP)
ISHIDA MICHIKO (JP)
SHINOZAKI ATSUHIKO (JP)
NOMURA YUTAKA (JP)
GOTO YASUNORI (JP)
Application Number:
PCT/JP1995/000632
Publication Date:
October 12, 1995
Filing Date:
March 31, 1995
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
MASAKI MITSUO (JP)
MIYAKE NORIHISA (JP)
TENDO ATSUSHI (JP)
ISHIDA MICHIKO (JP)
SHINOZAKI ATSUHIKO (JP)
NOMURA YUTAKA (JP)
GOTO YASUNORI (JP)
MASAKI MITSUO (JP)
MIYAKE NORIHISA (JP)
TENDO ATSUSHI (JP)
ISHIDA MICHIKO (JP)
SHINOZAKI ATSUHIKO (JP)
NOMURA YUTAKA (JP)
GOTO YASUNORI (JP)
International Classes:
C07D275/06; C07D279/02; C07D417/06; (IPC1-7): C07D275/04; C07D275/06; C07D279/02; C07D279/08; C07D281/02; C07D281/10; C07D283/00; C07D417/06; A61K31/425; A61K31/445; A61K31/535; A61K31/54; A61K31/55
Foreign References:
| JPS4623392B1 |
Other References:
JOURNAL OF ORGANIC CHEMISTRY, Vol. 31, No. 1, (1966), HAROLD ZINNES et al., "1, 2-Benzothiazines. III. The Preparation of 2H-1, 2-Benzothiazin-4(3H)-one 1, 1-Dioxide by the Acid-catalyzed Deacetylation of beta-Diketone", p. 162-165.
JOURNAL OF MEDICINAL CHEMISTRY, Vol. 16, No. 10, (1973), ENRICO SIANESI et al., "New Benzothiazines. 4. 1H-2, 3-Benzothiazin-4(3H)-one 2, 2-Diotide and 2H-1, 2-Benzothiazin-3(4H)-one 1, 1-Dioxide Nitrogen Derivatives with Central Nervous System Activity", p. 1133-1137.
CHEMICAL ABSTRACTS, Vol. 113, abstract no. 23893 (1990).
CHEMICAL ABSTRACTS, Vol. 113, abstract no. 6327 (1990).
ACTA NATURALIA DE L'ATENEO PARMENSE, Vol. 19, (1983), M.R. MINGIARDI, "Composti 1, 2-Benzisotiazolici a Potenziale Attivita beta-Bloccan te", p. 145-151.
ARZNEIM. -FORSCH., Vol. 9, (1982), R. BECKER et al., "The Metabolic Fate of Supidimide in the Rat", p. 1101-1111.
JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 15, No. 16, (1978), JOHN ASHBY et al., "The Transformation of Saccharin into Derivatives of Imidazo (1, 2-b) (1, 2)-Benzisothiazole and Benzo (g) (1, 2, 5) Thia Diazocine", p. 1009-1020.
See also references of EP 0753514A4
JOURNAL OF MEDICINAL CHEMISTRY, Vol. 16, No. 10, (1973), ENRICO SIANESI et al., "New Benzothiazines. 4. 1H-2, 3-Benzothiazin-4(3H)-one 2, 2-Diotide and 2H-1, 2-Benzothiazin-3(4H)-one 1, 1-Dioxide Nitrogen Derivatives with Central Nervous System Activity", p. 1133-1137.
CHEMICAL ABSTRACTS, Vol. 113, abstract no. 23893 (1990).
CHEMICAL ABSTRACTS, Vol. 113, abstract no. 6327 (1990).
ACTA NATURALIA DE L'ATENEO PARMENSE, Vol. 19, (1983), M.R. MINGIARDI, "Composti 1, 2-Benzisotiazolici a Potenziale Attivita beta-Bloccan te", p. 145-151.
ARZNEIM. -FORSCH., Vol. 9, (1982), R. BECKER et al., "The Metabolic Fate of Supidimide in the Rat", p. 1101-1111.
JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 15, No. 16, (1978), JOHN ASHBY et al., "The Transformation of Saccharin into Derivatives of Imidazo (1, 2-b) (1, 2)-Benzisothiazole and Benzo (g) (1, 2, 5) Thia Diazocine", p. 1009-1020.
See also references of EP 0753514A4
Download PDF:
Previous Patent: PYRIMIDINYL DERIVATIVES AS INTERLEUKIN INHIBITORS
Next Patent: PHYSIOLOGICALLY ACTIVE SUBSTANCE EI-1507
Next Patent: PHYSIOLOGICALLY ACTIVE SUBSTANCE EI-1507