ALKYLIDENE CARBAMATE AS KRAS INHIBITORS

Title:

ALKYLIDENE CARBAMATE AS KRAS INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2024/045066

Kind Code:

A1

Abstract:

Provided are certain alkylidenyl carbamate compounds that inhibit certain K-Ras proteins and are therefore useful for the treatment of cancers mediated by such proteins. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Inventors:

ZENG HAIQIANG (CN)
FU JIPING (US)
SUN YONGFENG (CN)
LOU YAN (US)
YU ZHIYONG (US)

Application Number:

PCT/CN2022/116281

Publication Date:

March 07, 2024

Filing Date:

August 31, 2022

Export Citation:

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Assignee:

NIKANG THERAPEUTICS INC (US)
ZENG HAIQIANG (CN)

International Classes:

C07D403/04; A61K31/519; A61P35/00; C07D471/04; C07D487/02; C07D519/00

Domestic Patent References:

WO2022173870A1	2022-08-18
WO2022068921A1	2022-04-07
WO2022061251A1	2022-03-24
WO2022042630A1	2022-03-03
WO2020146613A1	2020-07-16

Foreign References:

CN114615981A

2022-06-10

Attorney, Agent or Firm:

CHINA PATENT AGENT (H.K.) LTD. (CN)

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