ALKYLSULFONYL-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE] ANALOGS AS GLYT1 INHIBITORS, METHODS FOR MAKING SAME, AND USE OF SAME IN TREATING PSYCHIATRIC DISORDERS

Title:

ALKYLSULFONYL-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE] ANALOGS AS GLYT1 INHIBITORS, METHODS FOR MAKING SAME, AND USE OF SAME IN TREATING PSYCHIATRIC DISORDERS

Document Type and Number:

WIPO Patent Application WO/2010/102003

Kind Code:

A3

Abstract:

In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GIyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GIyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Inventors:

LINDSLEY CRAIG W (US)
CONN JEFFREY P (US)
WILLIAMS RICHARD (US)
JONES CARRIE K (US)
SHEFFLER DOUGLAS J (US)

Application Number:

PCT/US2010/026052

Publication Date:

March 10, 2011

Filing Date:

March 03, 2010

Export Citation:

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Assignee:

UNIV VANDERBILT (US)
LINDSLEY CRAIG W (US)
CONN JEFFREY P (US)
WILLIAMS RICHARD (US)
JONES CARRIE K (US)
SHEFFLER DOUGLAS J (US)

International Classes:

A01N43/42

Domestic Patent References:

WO2005046601A2	2005-05-26
WO2005087708A1	2005-09-22
WO2006050988A1	2006-05-18

Foreign References:

US5824486A

1998-10-20

Other References: