ALKYNYL HETEROCYCLIC COMPOUND FOR INHIBITING PROTEIN KINASE ACTIVITY

Title:

ALKYNYL HETEROCYCLIC COMPOUND FOR INHIBITING PROTEIN KINASE ACTIVITY

Document Type and Number:

WIPO Patent Application WO/2018/068739

Kind Code:

A1

Abstract:

The present invention relates to alkynyl heterocyclic compounds having inhibitory effects on the protein kinase activity, and to the preparation and use thereof. In particular, disclosed are alkynyl heterocyclic compounds as shown in formula (I) and a pharmaceutical composition comprising the compounds, a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a crystal form, a prodrug, or an isotope variant thereof. The compounds of the present invention can serve as protein kinase inhibitors for preparing anti-tumour drugs.

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Inventors:

WANG YIHAN (CN)
XING QINGFENG (CN)

Application Number:

PCT/CN2017/105789

Publication Date:

April 19, 2018

Filing Date:

October 12, 2017

Export Citation:

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Assignee:

SHENZHEN TARGETRX INC (CN)

International Classes:

C07D403/12; A61K31/437; A61K31/4439; A61K31/496; A61K31/506; A61K31/519; A61P35/00; A61P35/02; C07D239/42; C07D401/12

Domestic Patent References:

WO2006044823A2	2006-04-27
WO2015108490A2	2015-07-23
WO2015186137A1	2015-12-10
WO2009100536A1	2009-08-20
WO2014082578A1	2014-06-05
WO2014194667A1	2014-12-11
WO2015058661A1	2015-04-30
WO2001053274A1	2001-07-26

Foreign References:

CN101885722A	2010-11-17
CN103214480A	2013-07-24
CN105732614A	2016-07-06
CN104557939A	2015-04-29

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