ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

WIPO Patent Application WO/2018/049781

A1

The present invention relates to an alkynyl-substituted heterocyclic compound acting as an FGFR inhibitor, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a compound as shown in general formula (I) and a pharmaceutically acceptable salt thereof; a pharmaceutical composition including the compound or a pharmaceutically acceptable salt thereof; a method for treating and/or preventing FGFR-associated diseases, particularly tumours, by using the compound or a pharmaceutically acceptable salt thereof; and a preparation method for the compound or a pharmaceutically acceptable salt thereof. The present invention also relates to the use of the compound or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition including the compound or a pharmaceutically acceptable salt thereof in the preparation of a drug for treating and/or preventing FGFR-associated diseases, particularly tumours, wherein the definition of each substituent in general formula (I) is the same as that in the description.

CHEN XIANGYANG (CN)
GAO YINGXIANG (CN)
KONG XIANGLONG NORMAN (CN)

PCT/CN2017/072570

March 22, 2018

January 25, 2017

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BEIJING TIANCHENG PHARMA CO LTD (CN)

C07D403/04; A61K31/415; A61K31/4155; A61K31/454; A61P35/00; C07D231/14; C07D401/04; C07D401/06; C07D403/06

WO2013014039A1	2013-01-31
WO2015008844A1	2015-01-22

CLIN. CANCER RES., vol. 18, 2012
PLOS ONE, vol. 7, 2012, pages e36713
DRUG DISC. TODAY, vol. 19, 2014, pages 51
See also references of EP 3517535A4

CHINA PATENT AGENT (H.K.) LTD. (CN)

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