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Title:
ALLERGIC DISEASE THERAPEUTIC DRUG
Document Type and Number:
WIPO Patent Application WO/2014/133106
Kind Code:
A1
Abstract:
In the present invention, by administering a liposome containing pyranosyl ceramide compound, which is an unaltered NKT cell ligand, IL-21 production by iNKT cells is locally induced in the vicinity of IgE-producing B cells of the splenic marginal zone, apoptosis of these IgE-producing B cells is induced, and the like, and IgE production of IgE-producing B cells of the splenic marginal zone is effectively controlled.

Inventors:
ISHII, Yasuyuki (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
TASHIRO, Takuya (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
TANIGUCHI, Masaru (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
Application Number:
JP2014/054964
Publication Date:
September 04, 2014
Filing Date:
February 27, 2014
Export Citation:
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Assignee:
RIKEN (2-1 Hirosawa, Wako-shi Saitama, 98, 〒3510198, JP)
International Classes:
A61K31/715; A61K9/127; A61P37/08; A61P43/00; A61K31/7028
Domestic Patent References:
WO2005120574A1
WO2011096536A1
WO2007080977A1
WO2005000348A2
Foreign References:
JP2011519847A
JP2006265212A
JP2010523724A
Other References:
YASUYUKI ISHII: 'Tokushu: Seitai Bogyo Mechanism no Bunshi Kiban Allergy Shikkan no Yobo Chiryo no Tenbo' JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY vol. 81, no. 3, 2009, pages 209 - 217
YASUYUKI ISHII: 'Therapy for allergic diseases by liposome formulations including allergens and ligands for NKT cells' CLINICAL IMMUNOLOGY & ALLERGOLOGY vol. 49, no. 3, 2008, pages 325 - 329
TASHIRO T. ET AL.: 'RCAI-61, the 6'-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-y in vivo' TETRAHEDRON LETTERS vol. 49, no. 48, 2008, pages 6827 - 30
YASUYUKI ISHII: 'Men'eki Ryoho Update IX. Allergen Tokuiteki Men'eki Yokusei Liposome Seizai' ALLERGOLOGY & IMMUNOLOGY vol. 18, no. 6, 2011, pages 73 - 79
HEGDE S ET AL.: 'Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells.' IMMUNOLOGY. vol. 130, no. 4, 2010, pages 471 - 83
MICHISHIGE HARADA ET AL.: 'NKT Saibo ni yoru IgE Sansei Chosetsu no Atarashii Mechanism' MEDICAL SCIENCE DIGEST vol. 33, no. 7, 2007, pages 8 - 11
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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