Title:
ALLERGIC DISEASE THERAPEUTIC DRUG
Document Type and Number:
WIPO Patent Application WO/2014/133106
Kind Code:
A1
Abstract:
In the present invention, by administering a liposome containing pyranosyl ceramide compound, which is an unaltered NKT cell ligand, IL-21 production by iNKT cells is locally induced in the vicinity of IgE-producing B cells of the splenic marginal zone, apoptosis of these IgE-producing B cells is induced, and the like, and IgE production of IgE-producing B cells of the splenic marginal zone is effectively controlled.
Inventors:
ISHII YASUYUKI (JP)
TASHIRO TAKUYA (JP)
TANIGUCHI MASARU (JP)
TASHIRO TAKUYA (JP)
TANIGUCHI MASARU (JP)
Application Number:
PCT/JP2014/054964
Publication Date:
September 04, 2014
Filing Date:
February 27, 2014
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
A61K31/715; A61K9/127; A61P37/08; A61P43/00; A61K31/7028
Domestic Patent References:
| WO2005120574A1 | 2005-12-22 | |||
| WO2011096536A1 | 2011-08-11 | |||
| WO2007080977A1 | 2007-07-19 | |||
| WO2005000348A2 | 2005-01-06 |
Foreign References:
| JP2011519847A | 2011-07-14 | |||
| JP2006265212A | 2006-10-05 | |||
| JP2010523724A | 2010-07-15 |
Other References:
YASUYUKI ISHII: "Tokushu: Seitai Bogyo Mechanism no Bunshi Kiban Allergy Shikkan no Yobo Chiryo no Tenbo", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 81, no. 3, 2009, pages 209 - 217
YASUYUKI ISHII: "Therapy for allergic diseases by liposome formulations including allergens and ligands for NKT cells", CLINICAL IMMUNOLOGY & ALLERGOLOGY, vol. 49, no. 3, 2008, pages 325 - 329
TASHIRO T. ET AL.: "RCAI-61, the 6'-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-y in vivo", TETRAHEDRON LETTERS, vol. 49, no. 48, 2008, pages 6827 - 30
YASUYUKI ISHII: "Men'eki Ryoho Update IX. Allergen Tokuiteki Men'eki Yokusei Liposome Seizai", ALLERGOLOGY & IMMUNOLOGY, vol. 18, no. 6, 2011, pages 73 - 79
HEGDE S ET AL.: "Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells.", IMMUNOLOGY., vol. 130, no. 4, 2010, pages 471 - 83
MICHISHIGE HARADA ET AL.: "NKT Saibo ni yoru IgE Sansei Chosetsu no Atarashii Mechanism", MEDICAL SCIENCE DIGEST, vol. 33, no. 7, 2007, pages 8 - 11
YASUYUKI ISHII: "Therapy for allergic diseases by liposome formulations including allergens and ligands for NKT cells", CLINICAL IMMUNOLOGY & ALLERGOLOGY, vol. 49, no. 3, 2008, pages 325 - 329
TASHIRO T. ET AL.: "RCAI-61, the 6'-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-y in vivo", TETRAHEDRON LETTERS, vol. 49, no. 48, 2008, pages 6827 - 30
YASUYUKI ISHII: "Men'eki Ryoho Update IX. Allergen Tokuiteki Men'eki Yokusei Liposome Seizai", ALLERGOLOGY & IMMUNOLOGY, vol. 18, no. 6, 2011, pages 73 - 79
HEGDE S ET AL.: "Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells.", IMMUNOLOGY., vol. 130, no. 4, 2010, pages 471 - 83
MICHISHIGE HARADA ET AL.: "NKT Saibo ni yoru IgE Sansei Chosetsu no Atarashii Mechanism", MEDICAL SCIENCE DIGEST, vol. 33, no. 7, 2007, pages 8 - 11
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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