Title:
ALPHA-GLOBIN OVEREXPRESSION VECTOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/199552
Kind Code:
A1
Abstract:
Disclosed are an alpha-globin overexpression vector and an application thereof. The alpha-globin overexpression vector sequentially comprises: (1) a locus control region, an alpha-globin promoter, an HBA2 gene and a HBA2 gene 3'sequence fragment, the locus control region being HS40; or (2) locus control regions HS4, HS3 and HS2, a beta-globin promoter, an HBA2 gene and a HBB gene 3'sequence fragment. The overexpression vector provided by the present invention can efficiently transduce a target gene, can stably express the target gene for a long time, and has high infection efficiency and expression stability.
Inventors:
WU YUXUAN (CN)
CHENG YAN (CN)
XU SAIJUAN (CN)
ZHAO FEIYAN (CN)
WANG FEI (CN)
XI ZAIXI (CN)
LIU MINGYAO (CN)
CHENG YAN (CN)
XU SAIJUAN (CN)
ZHAO FEIYAN (CN)
WANG FEI (CN)
XI ZAIXI (CN)
LIU MINGYAO (CN)
Application Number:
PCT/CN2022/082108
Publication Date:
September 29, 2022
Filing Date:
March 21, 2022
Export Citation:
Assignee:
UNIV EAST CHINA NORMAL (CN)
BRL MEDICINE INC (CN)
BRL MEDICINE INC (CN)
International Classes:
C12N15/867; A61K38/41; A61P7/00
Foreign References:
| CN110106203A | 2019-08-09 | |||
| CN108012545A | 2018-05-08 | |||
| CN111363756A | 2020-07-03 | |||
| CN109294994A | 2019-02-01 | |||
| CN110564770A | 2019-12-13 | |||
| US6022738A | 2000-02-08 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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