Title:
ALPHA PROTEIN KINASE 1 INHIBITORS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2022/063152
Kind Code:
A1
Abstract:
Provided are compounds of Formula I, compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).
Inventors:
LIU DANYANG (CN)
XU CONG (CN)
MELVIN LAWRENCE S (CN)
WEI XIONG (CN)
LI TONGRUEI RAYMOND (CN)
FAN JIEQING (CN)
PAN YANFANG (CN)
DANG HUAIXIN (CN)
LICHENSTEIN HENRI (CN)
XU TIAN (CN)
XU CONG (CN)
MELVIN LAWRENCE S (CN)
WEI XIONG (CN)
LI TONGRUEI RAYMOND (CN)
FAN JIEQING (CN)
PAN YANFANG (CN)
DANG HUAIXIN (CN)
LICHENSTEIN HENRI (CN)
XU TIAN (CN)
Application Number:
PCT/CN2021/119801
Publication Date:
March 31, 2022
Filing Date:
September 23, 2021
Export Citation:
Assignee:
SHANGHAI YAO YUAN BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D417/12; A61K31/4178; A61K31/422; A61K31/427; A61P29/00; A61P35/00; C07D277/46; C07D403/12; C07D413/12; C07D417/14
Domestic Patent References:
| WO2008057862A2 | 2008-05-15 | |||
| WO2020176863A1 | 2020-09-03 | |||
| WO2019007362A1 | 2019-01-10 |
Other References:
DATABASE REGISTRY 13 May 2005 (2005-05-13), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -850402-11-8 REGISTRY ED -Entered STN: 13 May 2005 CN -Formamide, N-[4-[4-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-4-yl]-2- thiazolyl]-(CA INDEX NAME)", XP055915146, retrieved from STN Database accession no. 850402-11-8
DATABASE REGISTRY 22 September 2020 (2020-09-22), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -2484862-72-6 REGISTRY ED -Entered STN: 22 Sep 2020 CN -1H-Pyrrole-2-carboxamide, N-[4-(1-phenylethyl)-2-thiazolyl]-1-(4- pyridinylmethyl)-(CA INDEX NAME)", XP055915150, retrieved from STN Database accession no. 2484862-72-6
DATABASE REGISTRY 21 December 2017 (2017-12-21), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -2162783-43-7 REGISTRY ED -Entered STN: 21 Dec 2017 CN -Carbamic acid, N-[6-[hydroxy(3-methylphenyl)methyl]-2-pyridinyl]-, 1,1-dimethylethyl ester (CA INDEX NAME)", XP055915152, retrieved from STN Database accession no. 2162783-43-7
DATABASE REGISTRY 22 September 2020 (2020-09-22), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -2484862-72-6 REGISTRY ED -Entered STN: 22 Sep 2020 CN -1H-Pyrrole-2-carboxamide, N-[4-(1-phenylethyl)-2-thiazolyl]-1-(4- pyridinylmethyl)-(CA INDEX NAME)", XP055915150, retrieved from STN Database accession no. 2484862-72-6
DATABASE REGISTRY 21 December 2017 (2017-12-21), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -2162783-43-7 REGISTRY ED -Entered STN: 21 Dec 2017 CN -Carbamic acid, N-[6-[hydroxy(3-methylphenyl)methyl]-2-pyridinyl]-, 1,1-dimethylethyl ester (CA INDEX NAME)", XP055915152, retrieved from STN Database accession no. 2162783-43-7
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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