Title:
ALUMINUM-MANGANESE COMPOSITE NANOCRYSTAL, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/123959
Kind Code:
A1
Abstract:
An aluminum-manganese composite nanocrystal, and a preparation method therefor and the use thereof. The method for preparing the aluminum-manganese composite nanocrystal comprises: step 1, mixing an aluminum salt solution, a manganese salt solution and an anionic adjuvant solution to obtain a mixture, and adjusting the pH value of the mixture to 5.5-8.5; and step 2, heating the mixture for a reaction, and washing the obtained solid reactant to obtain the aluminum-manganese composite nanocrystal. According to the aluminum-manganese composite nanocrystal prepared using the preparation method and the use thereof in the preparation of a vaccine adjuvant, a pharmaceutical composition, a drug delivery carrier or an immunogenic composition, the technical problem that an existing aluminum adjuvant cannot activate humoral immunity and cell immunity at the same time can be effectively solved.
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Inventors:
CHEN CHUNYING (CN)
WANG YALING (CN)
ZHAO YULIANG (CN)
WANG YALING (CN)
ZHAO YULIANG (CN)
Application Number:
PCT/CN2022/102747
Publication Date:
July 06, 2023
Filing Date:
June 30, 2022
Export Citation:
Assignee:
THE GBA NAT INSTITUTE FOR NANOTECHNOLOGY INNOVATION (CN)
International Classes:
A61K39/39; A61K45/00; A61K47/02; A61P35/00; A61P37/04; B82Y5/00; B82Y40/00
Domestic Patent References:
| WO2020211857A1 | 2020-10-22 |
Foreign References:
| CN114028559A | 2022-02-11 | |||
| CN110665000A | 2020-01-10 | |||
| CN109395075A | 2019-03-01 | |||
| US20190134191A1 | 2019-05-09 |
Other References:
SHI SHUTING, ZHU HAORU, XIA XINYU, LIANG ZHIHUI, MA XUEHU, SUN BINGBING: "Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 37, no. 24, 1 May 2019 (2019-05-01), AMSTERDAM, NL , pages 3167 - 3178, XP093076133, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2019.04.055
RUWONA, TINASHE B. ET AL.,: "Toward understanding the mechanism underlying the strong adjuvant activity of aluminum salt nanoparticles,", VACCINE,, vol. 34, 5 May 2016 (2016-05-05), pages 3059 - 3067, XP029569630, DOI: 10.1016/j.vaccine.2016.04.081
RUWONA, TINASHE B. ET AL.,: "Toward understanding the mechanism underlying the strong adjuvant activity of aluminum salt nanoparticles,", VACCINE,, vol. 34, 5 May 2016 (2016-05-05), pages 3059 - 3067, XP029569630, DOI: 10.1016/j.vaccine.2016.04.081
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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