Title:
AMELIORATING AGENT FOR FEMALE-SPECIFIC PHYSICAL AND/OR MENTAL UNPLEASANT SYMPTOM
Document Type and Number:
WIPO Patent Application WO/2017/154865
Kind Code:
A1
Abstract:
The present invention provides an ameliorating agent for a female-specific physical and/or mental unpleasant symptom, which comprises γ-tocopherol and/or equol.
Inventors:
UENO TOMOMI (JP)
DEGUCHI TOMOKO (JP)
ONODA ATSUKO (JP)
DEGUCHI TOMOKO (JP)
ONODA ATSUKO (JP)
Application Number:
PCT/JP2017/008892
Publication Date:
September 14, 2017
Filing Date:
March 07, 2017
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
A61K31/355; A23L33/10; A23L33/15; A61K31/353; A61K36/48; A61P15/12; A61P25/04; A61P25/18; A61P25/22; A61P25/24; A61P43/00
Foreign References:
| JP2003300879A | 2003-10-21 |
Other References:
KATO, S. ET AL.: "The effects of y-tocopherol administration on pretibial edema in young women with premenstrual syndrome", ACTA MED. NAGASAKI., vol. 53, no. 3, 2008, pages 59 - 64, XP055415619, ISSN: 0001-6055
LONDON , R.S. ET AL.: "Efficacy of alpha- tocopherol in the treatment of the premenstrual syndrome", J. REPROD. MED., vol. 32, no. 6, 1987, pages 400 - 404, XP009512413, ISSN: 0024-7758
J IANG, Q. ET AL.: "gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 21, 2000, pages 11494 - 11499, XP002190542
JIANG, Q. ET AL.: "Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases", PROC. NATL. ACAD. SCI. USA, vol. 105, no. 51, 2008, pages 20464 - 20469, XP055415626
KIM, H.W. ET AL.: "Intake of dietary soy isoflavones in relation to perimenstrual symptoms of Korean women living in the USA", NURS. HEALTH SCI., vol. 8, no. 2, 2006, pages 108 - 113, XP055415630
BRYANT, M. ET AL.: "Effect of consumption of soy isoflavones on behavioural, somatic and affective symptoms in women with premenstrual syndrome", BR. J. NUTR., vol. 93, no. 5, 2005, pages 731 - 739, XP055415631, ISSN: 0007-1145
KANDA, Y. ET AL.: "The influence of equol production causes to mental complaints in premenstrual syndrome", BULLETIN OF TOKYO HEALTHCARE UNIVERSITY, vol. 2, no. 1, 2006, pages 39 - 42, XP009512455, ISSN: 1882-4455
ASO, T.: "Equol improves menopausal symptoms in Japanese women", J. NUTR., vol. 140, no. 7, 2010, pages 1386S - 1389S, XP055415631
See also references of EP 3427731A4
LONDON , R.S. ET AL.: "Efficacy of alpha- tocopherol in the treatment of the premenstrual syndrome", J. REPROD. MED., vol. 32, no. 6, 1987, pages 400 - 404, XP009512413, ISSN: 0024-7758
J IANG, Q. ET AL.: "gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 21, 2000, pages 11494 - 11499, XP002190542
JIANG, Q. ET AL.: "Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases", PROC. NATL. ACAD. SCI. USA, vol. 105, no. 51, 2008, pages 20464 - 20469, XP055415626
KIM, H.W. ET AL.: "Intake of dietary soy isoflavones in relation to perimenstrual symptoms of Korean women living in the USA", NURS. HEALTH SCI., vol. 8, no. 2, 2006, pages 108 - 113, XP055415630
BRYANT, M. ET AL.: "Effect of consumption of soy isoflavones on behavioural, somatic and affective symptoms in women with premenstrual syndrome", BR. J. NUTR., vol. 93, no. 5, 2005, pages 731 - 739, XP055415631, ISSN: 0007-1145
KANDA, Y. ET AL.: "The influence of equol production causes to mental complaints in premenstrual syndrome", BULLETIN OF TOKYO HEALTHCARE UNIVERSITY, vol. 2, no. 1, 2006, pages 39 - 42, XP009512455, ISSN: 1882-4455
ASO, T.: "Equol improves menopausal symptoms in Japanese women", J. NUTR., vol. 140, no. 7, 2010, pages 1386S - 1389S, XP055415631
See also references of EP 3427731A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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