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Title:
AMELIORATION AND TREATMENT OF PERINATAL BRAIN DAMAGE WITH PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2017/199976
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel use of pluripotent stem cells (Muse cells) for medical purposes in regenerative medicine. The present invention provides a cell preparation and a pharmaceutical composition both for ameliorating and treating perinatal brain damage including learning disability and motor disability, each of the cell preparation and the pharmaceutical composition containing SSEA-3-positive pluripotent stem cells separated from a mesenchymal tissue collected from a living body or cultured mesenchymal cells. The cell preparation according to the present invention relies on a mechanism that Muse cells are administered to a subject having the above-mentioned damage to cause the engraftment of the Muse cells in a damaged brain tissue, thereby ameliorating and treating the damage.

Inventors:
SATO, Yoshiaki (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
SUZUKI, Toshihiko (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
SHIMIZU, Shinobu (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
MIZUNO, Masaaki (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
HAYAKAWA, Masahiro (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
DEZAWA, Mari (2-1 Seiryo-machi, Aoba-ku, Sendai-sh, Miyagi 75, 〒9808575, JP)
Application Number:
JP2017/018416
Publication Date:
November 23, 2017
Filing Date:
May 16, 2017
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (1 Furo-cho, Chikusa-ku Nagoya-sh, Aichi 01, 〒4648601, JP)
LIFE SCIENCE INSTITUTE, INC. (1-1 Marunouchi 1-chome, Chiyoda-ku Tokyo, 51, 〒1008251, JP)
International Classes:
A61K35/545; A61K35/30; A61P1/00; A61P11/00; A61P21/00; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/18; A61P25/28; C12N5/0775
Domestic Patent References:
WO2011007900A12011-01-20
Other References:
INEKO KATO: "Teisansosei Kyoketsusei Nosho ni yoru Nosei Mahi- Teisansosei Kyoketsusei Nosho no Chiryo: Senshinteki Chiryoho", PERINATAL MEDICINE, vol. 43, no. 2, 10 February 2013 (2013-02-10), pages 208 - 12, ISSN: 0386-9881
YUICHIRO SUGIYAMA ET AL.: "Shinseiji Teisansosei Kyoketsusei Nosho Model Rat ni Okeru Kan'yokei Kansaibo Ryoho no Kento", REGENERATIVE MEDICINE, THE 15TH CONGRESS OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE PROGRAM·SHOROKU, vol. 15, 1 February 2016 (2016-02-01), ISSN: 1347-7919
HATTORI, T. ET AL.: "Administration of Umbilical Cord Blood Cells Transiently Decreased Hypoxic- Ischemic Brain Injury in Neonatal Rats", DEV NEUROSCI, vol. 37, 2015, pages 95 - 104, XP002474952, ISSN: 0378-5866
TOSHIHIKO SUZUKI: "Muse-saibo o Mochiita Shusanki Noshogai no Shinki Chiryo Kaihatsu", KAKEN, 4 April 2014 (2014-04-04), Retrieved from the Internet [retrieved on 20170601]
TOSHIHIKO SUZUKI: "Muse-saibo o Mochiita Shusanki Noshogai no Shinki Chiryo Kaihatsu", 2014 NENDO JISSHIREI HOKOKUSHO, 6 January 2017 (2017-01-06), Retrieved from the Internet [retrieved on 20170601]
TOSHIHIKO SUZUKI: "Muse-saibo o Mochiita Shusanki Noshogai no Shinki Chiryo Kaihatsu", 2015 NENDO JISSHIREI HOKOKUSHO, 6 January 2017 (2017-01-06), Retrieved from the Internet [retrieved on 20170601]
TOSHIHIKO SUZUKI: "Shinseiji Teisansosei Kyoketsusei Nosho ni Taisuru Multilineage- differentiating stress enduring cells o Mochiita Kansaibo Ryoho", JOURNAL OF JAPAN SOCIETY OF PERINATAL AND NEONATAL MEDICINE, vol. 52, no. 2, June 2016 (2016-06-01), pages 608, ISSN: 1348-964X
YOSHIAKI SATO: "Shusanki Shikkan ni Taisuru Muse-saibo o Mochiita Shinki Chiryoho no Kaihatsu", REGENERATIVE MEDICINE THE 16TH CONGRESS OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE PROGRAM·SHOROKU, vol. 16, 2017, pages 179, ISSN: 1347-7919
Attorney, Agent or Firm:
AOKI, Atsushi et al. (SEIWA PATENT & LAW, Toranomon 37 Mori Bldg. 5-1, Toranomon 3-chome, Minato-k, Tokyo 23, 〒1058423, JP)
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